Zobrazeno 1 - 10
of 3 276
pro vyhledávání: '"nf–κb pathway"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To evaluate the levels of YKL40, IL-6(interleukin-6), IL-8(interleukin-8), IL-10(interleukin-10), TNF-α (tumor necrosis factor-α) in OSAS (obstructive sleep apnea syndrome)children and explore the mechanism of YKL40 promoting inflammatory
Externí odkaz:
https://doaj.org/article/1190fc0d2eef4d35b6891619815a48e1
Autor:
Xiaowen Huang, Pengju Wei, Cheng Fang, Min Yu, Shilun Yang, Linhui Qiu, Yu Wang, Aimin Xu, Ruby Lai Chong Hoo, Junlei Chang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract The blood-brain barrier (BBB) is a critical interface that maintains the central nervous system homeostasis by controlling the exchange of substances between the blood and the brain. Disruption of the BBB plays a vital role in the developmen
Externí odkaz:
https://doaj.org/article/b51dc661b9f841bcb71c732f4338d00d
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background: Histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5) are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher selectivity for HDAC4/5. This study aimed to explore the expression and subcellular
Externí odkaz:
https://doaj.org/article/6cfadd4f34824f219325a01672b312d5
Autor:
Riya Thapa, Ehssan Moglad, Ahsas Goyal, Asif Ahmad Bhat, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Haider Ali, Brian Gregory Oliver, Ronan MacLoughlin, Harish Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 991-1017 (2024)
One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytopla
Externí odkaz:
https://doaj.org/article/3a63641c2bc8460b81a8e26ddd1b49f8
Publikováno v:
Journal of Men's Health, Vol 20, Iss 8, Pp 63-68 (2024)
Delayed wound healing is one vital complication of diabetes mellitus (DM) that adversely impacts patient quality of life. Infliximab (INF), a monoclonal tumor necrosis factor α (TNF-α) antibody, has been investigated for its therapeutic potential a
Externí odkaz:
https://doaj.org/article/6e8289e579bc458c94a3450a9397b4a4
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Cellular senescence features irreversible growth arrest and secretion of multiple proinflammatory cytokines. Cyclic GMP-AMP synthase (cGAS) detects DNA damage and activates the DNA-sensing pathway, resulting in the upregulation of
Externí odkaz:
https://doaj.org/article/4ebfa52d0ab24ecea6a058d588de2786
Autor:
Yang Ji, Chuangye Ni, Yanjun Shen, Zhenggang Xu, Lei Tang, Fei Yu, Lingbang Zhu, Hao Lu, Chuanyong Zhang, Shikun Yang, Xuehao Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Background Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding the functions and underlying mechanisms of circRNAs in tumor development holds promise for uncover
Externí odkaz:
https://doaj.org/article/a9a119303d564d21bb40e4324902baa3
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2693-2712 (2024)
Yang Zhao,1,* Yi-Han Wang,2,* Wei-Chao Tu,1 Da-Wei Wang,1 Mu-Jun Lu,3,4 Yuan Shao1 1Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, 201800, People’s Republic of China; 2Departme
Externí odkaz:
https://doaj.org/article/ed93b4774ef94ce9b5493b32dcf9713b
Publikováno v:
Journal of Men's Health, Vol 20, Iss 6, Pp 85-91 (2024)
Colon cancer (CC) ranks among the most common malignant tumors globally. Providing theoretical support is essential to controlling CC and improving patients’ prognoses. Beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), a protein-coding gene that
Externí odkaz:
https://doaj.org/article/c558c3b1d21d4237a9d8d6bbd52b907a
Publikováno v:
BMC Oral Health, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Human periodontal ligament stem cells (hPDLSCs) are important candidate seed cells for periodontal tissue engineering, but the presence of lipopolysaccharide(LPS) in periodontal tissues inhibits the self-renewal and osteogenic dif
Externí odkaz:
https://doaj.org/article/50becedebd0b4fc5b2b676ad6831367c