Zobrazeno 1 - 10
of 109
pro vyhledávání: '"new therapeutic targets"'
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 1, Pp 1-15 (2024)
Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis. It is still being explored in depth due to its complex molecular mechanisms of occurrence and development. Lipids play a crucial role in cells by participating in energ
Externí odkaz:
https://doaj.org/article/7710fbc3c62043b0a37e73b35caba0d0
Autor:
Luigi Sansone, Federica Barreca, Manuel Belli, Michele Aventaggiato, Andrea Russo, Giulietta A. Perrone, Matteo A. Russo, Marco Tafani, Andrea Frustaci
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d390c9eecca3425893ce2e956abb79d7
Autor:
Luigi Sansone, Federica Barreca, Manuel Belli, Michele Aventaggiato, Andrea Russo, Giulietta A. Perrone, Matteo A. Russo, Marco Tafani, Andrea Frustaci
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionFabry’s disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the lysosomes of many tissues. FD is due to loss-of-function mutations of α-galactos
Externí odkaz:
https://doaj.org/article/60b1bf9d8cb343589aee61222b849e32
Autor:
Johann E. Bedoya-Cardona, Marcela Rubio-Carrasquilla, Iliana M. Ramírez-Velásquez, Mario S. Valdés-Tresanco, Ernesto Moreno
Publikováno v:
Molecules, Vol 28, Iss 2, p 692 (2023)
Invasive fungal infections represent a public health problem that worsens over the years with the increasing resistance to current antimycotic agents. Therefore, there is a compelling medical need of widening the antifungal drug repertoire, following
Externí odkaz:
https://doaj.org/article/83ef0f13d2d84304acc2e585226348e8
Autor:
Sara Ilari, Stefania Proietti, Patrizia Russo, Valentina Malafoglia, Micaela Gliozzi, Jessica Maiuolo, Francesca Oppedisano, Ernesto Palma, Carlo Tomino, Massimo Fini, William Raffaeli, Vincenzo Mollace, Stefano Bonassi, Carolina Muscoli
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2361 (2022)
The control of neuropathic pain is a leading challenge in modern medicine. Traditional medicine has, for a long time, used natural compounds such as nutraceuticals for this purpose, and extensive evidence has supported their role in controlling oxida
Externí odkaz:
https://doaj.org/article/7e07aeb673914818a51ce84251a6f5c0
Akademický článek
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Akademický článek
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Autor:
Hwei-Fang Tsai, Ping-Ning Hsu
Publikováno v:
Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-8 (2017)
Abstract Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effective targets in treating cancer.
Externí odkaz:
https://doaj.org/article/9a3f15f3823f4eb4beb7ce91a5b5faac
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with an aging population. In the last few decades, due to the devastating nature of these diseases, the research of biomarkers has become crucial to enable adequate tr
Externí odkaz:
https://doaj.org/article/d68874c02f0445a1ba71a103abc3a512
Autor:
Emily Kim, Stefan Zschiedrich
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
von Hippel–Lindau (VHL) disease is an autosomal dominant syndrome caused by mutations in the VHL tumor-suppressor gene, leading to the dysregulation of many hypoxia-induced genes. Affected individuals are at increased risk of developing recurrent a
Externí odkaz:
https://doaj.org/article/40989d0407924c2dac5b2a91138d277a