Zobrazeno 1 - 10
of 218
pro vyhledávání: '"new approach methodology"'
Autor:
Marcos Felipe de Oliveira Galvão, Caroline Scaramboni, Burcu Ünlü Endirlik, Antero Vieira Silva, Mattias Öberg, Simone Andréa Pozza, Tetsushi Watanabe, Poliany Cristiny de Oliveira Rodrigues, Pérola de Castro Vasconcellos, Ioannis Sadiktsis, Kristian Dreij
Publikováno v:
Environment International, Vol 190, Iss , Pp 108942- (2024)
Air pollution is an example of a complex environmental mixture with different biological activities, making risk assessment challenging. Current cancer risk assessment strategies that focus on individual pollutants may overlook interactions among the
Externí odkaz:
https://doaj.org/article/758f5428a82247f9b14deae10d4707d4
Autor:
Rita Hargitai, Lucia Parráková, Tünde Szatmári, Pablo Monfort-Lanzas, Valentina Galbiati, Karine Audouze, Florence Jornod, Yvonne C. M. Staal, Sabina Burla, Aline Chary, Arno C. Gutleb, Katalin Lumniczky, Rob J. Vandebriel, Johanna M. Gostner
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods. Although chemical-in
Externí odkaz:
https://doaj.org/article/ae3b6967199e4958a4694634ffb1d70d
Publikováno v:
Environment International, Vol 186, Iss , Pp 108607- (2024)
Practical, legal, and ethical reasons necessitate the development of methods to replace animal experiments. Computational techniques to acquire information that traditionally relied on animal testing are considered a crucial pillar among these so-cal
Externí odkaz:
https://doaj.org/article/a767a2aa373a49f3a02c1c05ccf101d6
Autor:
Giulia Motta, Maurizio Gualtieri, Rossella Bengalli, Melissa Saibene, Franco Belosi, Alessia Nicosia, Joan Cabellos, Paride Mantecca
Publikováno v:
Environment International, Vol 183, Iss , Pp 108420- (2024)
The production and use of nanomaterials (NMs) has increased over the last decades posing relevant questions on their risk after release and exposure of the population or sub-populations. In this context, the safe and sustainable by design (SSbD) appr
Externí odkaz:
https://doaj.org/article/2535836f474c4c92bcc7f5d3628bf3c4
Publikováno v:
Toxics, Vol 12, Iss 7, p 481 (2024)
Environmental chemicals, such as PFAS, exist as mixtures and are frequently encountered at varying concentrations, which can lead to serious health effects, such as cancer. Therefore, understanding the dose-dependent toxicity of chemical mixtures is
Externí odkaz:
https://doaj.org/article/8c0ff28ef2334161a50e699c37c90380
Publikováno v:
EFSA Journal, Vol 21, Iss S1, Pp n/a-n/a (2023)
Abstract Traditionally applied methodology in environmental risk assessment (ERA) has fallen out of step with technological advancements and regulatory requirements, challenging effectiveness and accuracy of the assessments. Extensive efforts have be
Externí odkaz:
https://doaj.org/article/31339bfbe45e42b4a898450dd53a22d3
Autor:
Alex Horánszky, Bachuki Shashikadze, Radwa Elkhateib, Salvo Danilo Lombardo, Federica Lamberto, Melinda Zana, Jörg Menche, Thomas Fröhlich, András Dinnyés
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Bisphenol A (BPA) exposure is associated with a plethora of neurodevelopmental abnormalities and brain disorders. Previous studies have demonstrated BPA-induced perturbations to critical neural stem cell (NSC) characteristics, such as proliferation a
Externí odkaz:
https://doaj.org/article/92bf0bc636c6474b9a585dfd0e55520b
Akademický článek
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Akademický článek
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Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
Autor:
Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induc
Externí odkaz:
https://doaj.org/article/ef322cf5e85e456eb141e4eefa521a86