Ambiguity of the influence of cytokines IL-8, IL-17A, TNFα, AND IFNγ on the antigen presenting CD66b+CD16+CD33+HLA-DR+ subpopulation of neutrophil granulocytes in children with acute hematogenic osteomyelitis

Autor: G. A. Chudilova, I. V. Nesterova, Yu. V. Teterin, K. I. Melkonyan, M. G. Atazhakhova, V. N. Chapurina, E. A. Chicherev

Publikováno v: Медицинская иммунология, Vol 26, Iss 5, Pp 1085-1092 (2024)

Dysfunctions of the immune system, in turn, of neutrophil granulocytes (NG), are the cause of the emergence and progression of the focus of infection in bone tissue and bone marrow in acute hematogenous osteomyelitis (AHO). When colonizing bones, S.

Externí odkaz: https://doaj.org/article/73246cfbdfe34907aac504e0692a5062

Integrative diagnostic criterion for evaluation of COVID-19 severity and the risk of post-COVID syndrome

Autor: I. V. Nesterova, M. G. Atazhakhova, V. A. Matushkina, Yu. V. Teterin, V. N. Gorodin, G. A. Chudilova

Publikováno v: Медицинская иммунология, Vol 26, Iss 3, Pp 545-554 (2024)

Pathophysiology of severe COVID-19 is characterized by changes in the number, phenotype, and function of neutrophil granulocytes (NG). Among the effector antiviral mechanisms of NG, the neutrophil extracellular traps (NETs) are among the most importa

Externí odkaz: https://doaj.org/article/acd7fce66e114b6a93fea3889832ae36

Antigen presenting subset of СD66b+CD16+CD33+HLA-DR+ neutrophilic granulocytes in acute osteomyelitis in children: Immunomodulating effects of immunotropic hexapeptide in an in vitro experimental system

Autor: I. V. Nesterova, G. A. Chudilova, Yu. V. Teterin, E. A. Chicherev, V. N. Chapurina, M. N. Mitropanova

Publikováno v: Медицинская иммунология, Vol 25, Iss 4, Pp 899-906 (2023)

Inclusion of neutrophilic granulocytes (NG) in inflammation depends on the expression of receptors providing the functions of NG. Acute osteomyelitis (AOM) occupies a central place among purulentinflammatory diseases in children. AOM purulent-necroti

Externí odkaz: https://doaj.org/article/f2d2fe9ae4e543ad9efb95038febd1b2

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In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

Autor: Solveig Lemmel, Markus Weckmann, Anna Wohlers, Adan Chari Jirmo, Ruth Grychtol, Isabell Ricklefs, Gyde Nissen, Anna Bachmann, Shantanu Singh, Juan Caicedo, Thomas Bahmer, Gesine Hansen, Erika Von Mutius, Klaus F. Rabe, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Anne E. Carpenter, Matthias Volkmar Kopp, Tim Becker, the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), Mustafa Abdo, Miguel Alcazar, Mira Berbig, Heike Biller, Xenia Bovermann, Folke Brinkmann, Mifflin-Rae Calveron, David S. DeLuca, Gesa Diekmann, Christian Dopfer, Markus Ege, Svenja Foth, Svenja Gaedcke, Karoline I. Gaede, Anika Habener, Christian Herzmann, Alexander Hose, Sabina Illi, Anne-Marie Kirsten, Naschla Kohistani-Greif, Inke R. König, Silke Van Koningsbruggen-Rietschel, Matthias V. Kopp, Johanna Kurz, Katja Landgraf-Rauf, Kristina Laubhahn, Lena Liboschik, Claudia Liebl, Berrit Liselotte Husstedt, Bin Liu, Nicole Maison, Aydin Malik, Carola Marzi, Meike Meyer, Catharina Nitsche, Frauke Pedersen, Mareike Price, Harald Renz, Ernst Rietschel, Barbara Roesler, Christina Schauberger, Tom Schildberg, Carsten Schmidt-Weber, Nicolaus Schwerk, Chrysanthi Skevaki, Alena Steinmetz, Laila Sultansei, Marlen Szewczyk, Dominik Thiele, Vera Veith, Gesche Voigt, Benjamin Waschki, Henrik Watz, Stefanie Weber, Nils Welchering, Esther Zeitlmann, Ulrich Zissler

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocytes (NGs) fro

Externí odkaz: https://doaj.org/article/fc7e3e168608484cb6c82625730f72c5