Zobrazeno 1 - 10
of 105
pro vyhledávání: '"neurotrophic tyrosine receptor kinase"'
Autor:
Piergiuseppe Colombo, Giuseppina Adriana Buonamassa, Anita Giulianini, Letizia Hassan, Noemi Rudini, Antonio Rizzo, Enrico Cavallo, Carlo Carnaghi, Salumeh Goudarzi, Sebastiano Mongiovì, Sarah Pafumi, Stefano Marletta
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Neurotrophic tyrosine receptor kinase (NTRK) fusions are infrequent genetic events that can occur in various tumor types. Specifically, NTRK-rearranged sarcoma has been observed in pediatric mesenchymal tumors and, to a lesser extent, in adult mesenc
Externí odkaz:
https://doaj.org/article/d6c4c93b7e1f4b779db9062ffa5215bd
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-5 (2024)
Abstract The Neurotrophic tyrosine receptor kinase (NTRK) family plays important roles in tumor progression and is involved in tumor immunogenicity. Here, we conducted a comprehensive bioinformatic and clinical analysis to investigate the characteris
Externí odkaz:
https://doaj.org/article/a3c9998f83d7480e80f8a80f4d4025f1
Modification of a Selective NTRK2 Agonist and Confirmation of Activity in a Glaucoma-on-a-Chip Model
Autor:
Fatemeh Nafian, Shahin Yazdani, Mohammad Javad Rasaee, Babak Kamali Doust Azad, Narsis Daftarian, Mozhgan Rezaei Kanavi
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 19, Iss 1, Pp 58-70 (2024)
Abstract Purpose: RNYK is a selective agonist of the neurotrophic tyrosine kinase receptor type 2 (NTRK2) which has been screened from a phage-displayed peptide library. Its sequence is SGVYKVAYDWQH, similar to a native NTRK2 ligand, that is, brain-d
Externí odkaz:
https://doaj.org/article/59e995f92eed44ccad282a3b8e54c41c
Autor:
Federica Zito Marino, Simona Buono, Marco Montella, Rosa Giannatiempo, Francesco Messina, Giovanni Casaretta, Grazia Arpino, Giulia Vita, Francesco Fiorentino, Luigi Insabato, Alessandro Sgambato, Michele Orditura, Renato Franco, Marina Accardo
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 5, Pp 367-377 (2023)
Abstract Triple‐negative breast cancer (TNBC) is usually an aggressive disease with a poor prognosis and limited treatment options. The neurotrophic tyrosine receptor kinase (NTRK) gene fusions are cancer type‐agnostic emerging biomarkers approve
Externí odkaz:
https://doaj.org/article/92e0f09f3c1947ca80404c43828e4f6a
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 274, Iss , Pp 116215- (2024)
Nicotine exposure from smoking constitutes a significant global public health concern. Furthermore, smoking represents a pivotal risk factor for head and neck squamous cell carcinoma (HNSCC). However, the influence of nicotine on HNSCC remains relati
Externí odkaz:
https://doaj.org/article/2adbf9eabdef430091e62540edb4f8a2
Autor:
Emanuela Palmerini, Giorgio Frega, Marco Gambarotti, Tommaso Frisoni, Marilena Cesari, Alberto Bazzocchi, Marco Miceli, Davide Maria Donati, Stefano Fanti, Cristina Nanni, Stefania Benini, Alessandra Longhi, Anna Paioli, Andrea Marrari, Rossella Hakim, Alberto Righi, Toni Ibrahim
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background: Neurotrophic tyrosine receptor kinase (NTRK) gene-fusion targeted molecules revolutionized the paradigm of treatment of a limited subgroup of cancers of various histologies. Entrectinib and larotrectinib obtained unprecedented response ra
Externí odkaz:
https://doaj.org/article/65afba1c23ad453fa34d144e8c213b50
Autor:
Catherine Cervi, Zoltán Sápi, Gábor Bedics, Erik Zajta, Lajos Hegyi, Judit Pápay, Katalin Dezső, Edit Varga, Katalin Mudra, Csaba Bödör, Monika Csóka
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Significant improvements in the survival rates of paediatric cancer have been achieved over the past decade owing to recent advances in therapeutic and diagnostic strategies. However, disease progression and relapse remain a major challenge for the c
Externí odkaz:
https://doaj.org/article/b616bb309499462a8e79867a9acfbbb7
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