Zobrazeno 1 - 10
of 19
pro vyhledávání: '"neurosteroidy"'
Autor:
Sivčev, Sonja
(EN) Purinergic P2X receptors are ATP-gated cation channels with multiple physiological roles and are emerging as important therapeutic targets in a range of diseases. P2X subunit consists of two transmembrane helices (TM1 and TM2), an extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::dbef2a62a0dc116eb57e448f360f08a7
http://www.nusl.cz/ntk/nusl-510561
http://www.nusl.cz/ntk/nusl-510561
Autor:
Krejčí, Lukáš
Allopregnanolone is a typical representative of neurosteroids. It can be formed by de novo synthesis directly in the CNS or as a metabolite of progesterone. It is an allosteric modulator of GABAA receptors, due to which it has anxiolytic, sedative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::93099374253726357a7d4f836b4317c2
http://www.nusl.cz/ntk/nusl-520667
http://www.nusl.cz/ntk/nusl-520667
Autor:
Naimová, Žaneta
NMDA receptors belong to the family of ionotropic glutamate receptors, and are involved in synaptic plasticity, learning and memory. However, overactivation by the agonist glutamate can lead to neuronal death - excitotoxicity. Exitotoxicity is a resu
Externí odkaz:
http://www.nusl.cz/ntk/nusl-404929
Autor:
Fraňková, Denisa
Kainate receptors belong to the family of glutamate receptors, which include NMDA, AMPA and δ receptors. Glutamate receptors are widely found in the brain and therefore they are very dynamically investigated, especially from view of pharmacology, be
Externí odkaz:
http://www.nusl.cz/ntk/nusl-356192
Autor:
Chrbolka, Pavel
(AJ) Tinnitus is not seen as a separate disease, but in terms of symptoms accompanying various diseases. The emergence of tinnitus is involved in a variety of risk factors. Relationship between tinnitus and blood flow of the ear is described in a rel
Externí odkaz:
http://www.nusl.cz/ntk/nusl-369426
Autor:
Naimová, Žaneta
The discovery of steroid compounds capable of synthesize or accumulation in CNS and PNS led to a question about their function. Neurosteroid compounds are capable of modulating synaptic transmission. Effect is direct and fast mediated through nongeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::76b3550dafcff9a6ea2e75ad51756009
http://www.nusl.cz/ntk/nusl-365458
http://www.nusl.cz/ntk/nusl-365458
Autor:
Fraňková, Denisa
Kainate receptors belong to the family of glutamate receptors, which include NMDA, AMPA and δ receptors. Glutamate receptors are widely found in the brain and therefore they are very dynamically investigated, especially from view of pharmacology, be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::d3fb3a1cad611d7d57b0ec9e086fe092
http://www.nusl.cz/ntk/nusl-356192
http://www.nusl.cz/ntk/nusl-356192
Autor:
Kapras, Vojtěch
Herein is reported the synthesis of molecular probes for action of neuroactive steroids in vitro and in living organisms. In the first part, preparation of enantiomeric pregnane steroids is investigated, ultimately resulting into the total synthesis
Externí odkaz:
http://www.nusl.cz/ntk/nusl-347460
Autor:
Švehla, Pavel
N-methyl-D-aspartate (NMDA) receptors are a subtype of receptors for major excitatory neurotransmitter glutamate in the central nervous system. Their activity is regulated by variety of allosteric modulators, including endogenous neurosteroids and th
Externí odkaz:
http://www.nusl.cz/ntk/nusl-331142
Autor:
Riedlová, Kamila
Molecular dynamics (MD) method allows the real-time monitoring of the system composed of molecules and atoms, such as phospholipid bilayer or biomolecule. Applications of MD are very common in drug design where the real experimental procedures could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::09670d0d0c48d0487c5b011ef1255f98
http://www.nusl.cz/ntk/nusl-342172
http://www.nusl.cz/ntk/nusl-342172