Zobrazeno 1 - 10
of 233
pro vyhledávání: '"neuropeptide processing"'
Autor:
Yesim Parman, Duygu Gezen-Ak, Arman Çakar, Hacer Durmus, Hasan Demirci, Erdinç Dursun, Merve Alaylıoğlu
Publikováno v:
Acta Neurologica Scandinavica. 144:640-646
Objectives Hereditary amyloidogenic transthyretin (ATTRv) amyloidosis is an autosomal dominant disorder caused by mutations of the transthyretin (TTR) gene. The mutant ATTRv protein causes a systemic accumulation of amyloid fibrils in various organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9724c649b8ea1731d1d03342f2322d
https://doi.org/10.1111/ane.13507
https://doi.org/10.1111/ane.13507
Autor:
Holly K. Gildea, Melissa G. Metcalf, Ashley E. Frakes, Sarah U. Tronnes, Jenni Durieux, Andrew Dillin, Samira Monshietehadi, Nazineen Kandahari, Raz Bar-Ziv
Publikováno v:
Science
Science (New York, N.Y.), vol 367, iss 6476
Science (New York, N.Y.), vol 367, iss 6476
Taking the stress out of life In the model organism Caenorhabditis elegans , a roundworm, it has been shown that neurons can communicate proteostasis to the periphery to affect aging. Frakes et al. have now identified astrocytelike glial cells that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908b8e02f6b8df8664eca7c5e542cf43
https://doi.org/10.1126/science.aaz6896
https://doi.org/10.1126/science.aaz6896
Publikováno v:
ACS Chemical Neuroscience. 10:1884-1891
Neuropeptides are chemical messengers that act to regulate a number of physiological processes, including feeding, reward, pain, and memory, among others. PEN is one of the most abundant hypothalamic neuropeptides; however, until recently, its target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd4022f3c8bd80a4595cb50bf5c8e12
https://doi.org/10.1021/acschemneuro.8b00559
https://doi.org/10.1021/acschemneuro.8b00559
Autor:
Jan Watteyne, Niels Ringstad, Gerben Menschaert, Liliane Schoofs, H. Robert Horvitz, Kurt Boonen, Steven J. Husson, Sven Van Bael, Wouter De Haes, Liesbet Temmerman
Publikováno v:
Journal of Biological Chemistry. 293:6052-6063
Neuropeptides constitute a vast and functionally diverse family of neurochemical signaling molecules and are widely involved in the regulation of various physiological processes. The nematode Caenorhabditis elegans is well-suited for the study of neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebc835aba91b2a0d02a7ebe8b12e369
https://doi.org/10.1074/jbc.ra117.000731
https://doi.org/10.1074/jbc.ra117.000731
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008297 (2019)
PLoS Genetics
PLoS Genetics
The avoidance of starvation is critical for the survival of most organisms, thus animals change behavior based on past nutritional conditions. Insulin signaling is important for nutritional state-dependent behavioral plasticity, yet the underlying re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467ba29ef99b42a944a54559b47ef734
https://doaj.org/article/63352357c72647a4a814b23868954f20
https://doaj.org/article/63352357c72647a4a814b23868954f20
Autor:
Dennis Pauls, Christian Wegener, Andreas Schlosser, Tim M. Schendzielorz, Jörg Kahnt, Gertrud Gramlich, Yasin Hamarat, Jens T. Vanselow, Luisa Trufasu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b0edfe55b25c8c02803834e91a189e
https://doi.org/10.1111/ejn.14516/v2/response1
https://doi.org/10.1111/ejn.14516/v2/response1
Publikováno v:
Expert review of endocrinologymetabolism. 7(2)
Transthyretin (TTR) is a plasma- and cerebrospinal fluid-circulating protein. Besides the primordially attributed systemic role as a transporter molecule of thyroxine (T4) and retinol (through the binding to retinol-binding protein [RBP]), TTR has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdb3d2f47a7b233f33cd873d59dda64
https://pubmed.ncbi.nlm.nih.gov/30764010
https://pubmed.ncbi.nlm.nih.gov/30764010
Autor:
Joerg Kahnt, Christian Wegener, Tim M. Schendzielorz, Gertrud Gramlich, Dennis Pauls, Luisa Trufasu, Jens T. Vanselow, Yasin Hamarat, Andreas Schlosser
Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular and biochemical mechanisms underlying preproprotein processing and the functional importance of processing enzymes are well characterised in mammals,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7016c5352b25af61c2ff112690fa948d
Autor:
Laura Bianchi, Lei Wang
Publikováno v:
Exp Neurol
Mounting evidence support that glia play a key role in organismal ageing. However, the mechanisms by which glia impact ageing are not understood. One of the processes that has significant impact on the rate of ageing is the unfolded protein response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fcc6d6af5bed3f5a8563480e422560
https://doi.org/10.1016/j.expneurol.2021.113648
https://doi.org/10.1016/j.expneurol.2021.113648