Zobrazeno 1 - 10
of 409
pro vyhledávání: '"neuronal toxicity"'
Autor:
Mohamed Kreir, Dea Putri, Fetene Tekle, Francesca Pibiri, Constantin d’Ydewalle, Karel Van Ammel, Helena Geys, Ard Teisman, David J. Gallacher, Hua Rong Lu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of pos
Externí odkaz:
https://doaj.org/article/6519f93f4908451c87b4f64f1cc25244
Autor:
Yaowei Guo, Junliang Chen, Wenyu Ji, Liang Xu, Yu Xie, Shu He, Chuying Lai, Kaiyu Hou, Zeru Li, Gong Chen, Zheng Wu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101102- (2023)
The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial injection of adeno-associated virus (AAV) is considered a relative
Externí odkaz:
https://doaj.org/article/e04e0dbdede7411d9b678529d684fb14
Autor:
Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim, Şevin Turcan
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived
Externí odkaz:
https://doaj.org/article/fa0f02994ce642d6bf67a50fef6ccde1
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 242-246 (2022)
Alzheimer disease (AD) is a devastating condition associated with loss of proteostasis control and autophagy failure, leading to progressive neuronal cell death. However, the relationship between the activity in macroautophagy (MA) and chaperone-medi
Externí odkaz:
https://doaj.org/article/9f106a2a07b447a9be1caa41f0a82028
Akademický článek
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Autor:
Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yun
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2993 (2022)
Acute kidney injury (AKI) is an inflammatory sequence. It can lead to distant organ injury, including damage to the central nervous system (CNS), mediated by increased circulating cytokines and other inflammatory mediators. It can also lead to increa
Externí odkaz:
https://doaj.org/article/47201f43b98c4174aac53dfe24611afe
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain. Methods Elisa,
Externí odkaz:
https://doaj.org/article/80f67bb6ca7b46c3abbbc32040d8a2b2
Autor:
Amber Woodard, Brandon Barbery, Reid Wilkinson, Jonathan Strozyk, Mathew Milner, Patrick Doucette, Jarred Doran, Kendra Appleby, Henry Atwill, Wade E. Bell, James E. Turner
Publikováno v:
AIMS Neuroscience, Vol 6, Iss 1, Pp 25-42 (2019)
Neuronal nitric oxide (nNO) has been shown to affect motor function in the brain. Specifically, nNO acts in part through regulation of dopamine (DA) release, transporter function, and the elicitation of neuroprotection/neurodegeneration of neurons in
Externí odkaz:
https://doaj.org/article/04fa1a918c1647549ab2843c6983fa2f
Autor:
Young J. Yauger, Sara Bermudez, Kasey E. Moritz, Ethan Glaser, Bogdan Stoica, Kimberly R. Byrnes
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Excessive iron contributes to oxidative stress after central nervous system injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory activation and contribute to oxidative stress. The relationship be
Externí odkaz:
https://doaj.org/article/0e25b285c80f45c9986786ddc117ebdb
Autor:
Schwarze, Benedikt, Korn, Alexander, Höfling, Corinna, Zeitschel, Ulrike, Krueger, Martin, Roßner, Steffen, Huster, Daniel
Fibril formation of amyloid β (Aβ) peptides is one of the key molecular events connected to Alzheimer's disease. The pathway of formation and mechanism of action of Aβ aggregates in biological systems is still object of very active research. To th
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A93819
https://ul.qucosa.de/api/qucosa%3A93819/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A93819/attachment/ATT-0/
