Zobrazeno 1 - 10
of 443
pro vyhledávání: '"neuronal hyperexcitability"'
Autor:
Naoki Ikegaya, Honoka Nakamura, Yutaro Takayama, Yohei Miyake, Takahiro Hayashi, Masaki Sonoda, Mitsuru Sato, Kensuke Tateishi, Jun Suenaga, Masao Takaishi, Yu Kitazawa, Misako Kunii, Hiroki Abe, Tomoyuki Miyazaki, Tetsuaki Arai, Manabu Iwasaki, Takayuki Abe, Tetsuya Yamamoto
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION The use of anti‐epileptic drugs (AEDs) in degenerative dementia (DD) remains uncertain. We aimed to evaluate the association of early AED administration with subsequent DD occurrence. METHODS Using a large nationwide database,
Externí odkaz:
https://doaj.org/article/a9e3e85dd375488d89766625af530235
Autor:
Min-Kaung-Wint-Mon, Hiroyuki Kida, Itsuki Kanehisa, Masahiko Kurose, Junko Ishikawa, Yuya Sakimoto, Paw-Min-Thein-Oo, Ryoichi Kimura, Dai Mitsushima
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1425 (2024)
Aβ1-42 (amyloid beta) oligomers, the major neurotoxic culprits in Alzheimer’s disease, initiate early pathophysiological events, including neuronal hyperactivity, that underlie aberrant network activity and cognitive impairment. Although several s
Externí odkaz:
https://doaj.org/article/ad1b3f9bcc6244e79bd90de8629dcfa8
Autor:
Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede, Manisha Patel
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102895- (2023)
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly de
Externí odkaz:
https://doaj.org/article/ed4713f353534d5c94fce6e8d5efe468
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the me
Externí odkaz:
https://doaj.org/article/5d51c9a6793745b090d33b2082300790
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100094- (2022)
Chronic migraine is one of the most devastating headache disorders. The estimated prevalence is 1.4–2.2% in the population. The factors which may predispose to the process of migraine progression include high frequency of migraine attacks, medicati
Externí odkaz:
https://doaj.org/article/0fddf23fd9e44b7a931335fe0bb8f317
Autor:
Anna B. Szabo, Benjamin Cretin, Fleur Gérard, Jonathan Curot, Emmanuel J. Barbeau, Jérémie Pariente, Lionel Dahan, Luc Valton
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mountain of liter
Externí odkaz:
https://doaj.org/article/ac70838b4609460cbfbbef557c04a041
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Tao Hu, Shan Li, Wen-Qi Liang, Shan-Shan Li, Min-Nan Lu, Bo Chen, Li Zhang, Rui Mao, Wan-Hai Ding, Wen-Wei Gao, Shi-Wen Chen, Yan-Bin XiYang, Jie Zhang, Xu-Yang Wang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Alzheimer disease is characterized by a progressive cognitive deficit and may be associated with an aberrant hyperexcitability of the neuronal network. Notoginsenoside R1 (R1), a major activity ingredient from Panax notoginseng, has demonstrated favo
Externí odkaz:
https://doaj.org/article/a24ec590a3f644a983b94c12ca2b1f02