Zobrazeno 1 - 10
of 2 713
pro vyhledávání: '"neuronal excitability"'
Autor:
Ryoko Uchida, Yasutaka Mukai, Taiju Amano, Kenji Sakimura, Keiichi Itoi, Akihiro Yamanaka, Masabumi Minami
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain reward system during chronic pain.
Externí odkaz:
https://doaj.org/article/f0a08a2e7f5f49858427c9703a97edec
Publikováno v:
Brain Research Bulletin, Vol 214, Iss , Pp 111008- (2024)
The infralimbic (IL) cortex dysfunction has been implicated in major depressive disorder (MDD), yet the precise cellular and molecular mechanisms remain poorly understood. In this study, we investigated the role of layer V pyramidal neurons in a mous
Externí odkaz:
https://doaj.org/article/275f19c12c8443a0b595c41bb8f20212
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degrada
Externí odkaz:
https://doaj.org/article/0e734578ed0f4d43ba683f16eaca8bd9
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the centr
Externí odkaz:
https://doaj.org/article/44915be6ad9d472d9d5dd85aed6e1445
Publikováno v:
Electronic Research Archive, Vol 32, Iss 1, Pp 90-108 (2024)
A high spike-timing precision characterized by a small variation in interspike intervals of neurons is important for information processing in various brain functions. An experimental study on fast-spiking interneurons has shown that inhibitory autap
Externí odkaz:
https://doaj.org/article/5974cabde7ff44ee8353d0ed2bc9cd47
Autor:
Farnaz Karimani, Afsaneh Asgari Taei, Mohammad-Reza Abolghasemi-Dehaghani, Mir-Shahram Safari, Leila Dargahi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of Alzheimer’s disease (AD), with some of the disease’s pathological processes originating from this area, making it one of the most crucial brain regio
Externí odkaz:
https://doaj.org/article/024ccfc3b9b94dd3ac7e9518c332cf73
Autor:
Munal B. Kandel, Gerald Z. Zhuang, William F. Goins, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Wai-Meng Kwok, Roy C. Levitt, Konstantinos D. Sarantopoulos
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Chronic pain is common and inadequately treated, making the development of safe and effective analgesics a high priority. Our previous data indicate that carbonic anhydrase-8 (CA8) expression in dorsal root ganglia (DRG) mediates analgesia via inhibi
Externí odkaz:
https://doaj.org/article/3621c8f032f6429ba118a169c8a8463e
Publikováno v:
World Neurosurgery: X, Vol 22, Iss , Pp 100328- (2024)
Drug-resistant epilepsy (DRE) poses a significant global challenge, impacting the well-being of patients. Anti-epileptic drugs often fail to effectively control seizures in individuals with DRE. This condition not only leads to persistent seizures bu
Externí odkaz:
https://doaj.org/article/4dbb60778a294be292f0187d59100a74
Autor:
Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi, Jacob Porter, Komi Gbedande, Brendan Prideaux, Thomas A. Green, Erin H. Seeley, Parimal Samir, Kelley T. Dineley, Gracie Vargas, Jia Zhou, Irma Cisneros, Robin Stephens, Fernanda Laezza
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-24 (2023)
Abstract Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the brain, behavioral changes, and mortality. Ho
Externí odkaz:
https://doaj.org/article/35303451441c4a8dbc90b35695ec8147