Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer’s Disease

Autor: Temitope Adeoye, Syed I. Shah, Angelo Demuro, David A. Rabson, Ghanim Ullah

Publikováno v: Cells, Vol 11, Iss 14, p 2167 (2022)

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca2+ influx through membrane-resident voltage-gated Ca2+ channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensivel

Externí odkaz: https://doaj.org/article/7be7f90cb2514c3c933243ce37cdee56

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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Autor: Ripke, S, O'Dushlaine, C, Chambert, K, Moran, Jl, Kähler, Ak, Akterin, S, Bergen, Se, Collins, Al, Crowley, Jj, Fromer, M, Kim, Y, Lee, Sh, Magnusson, Pk, Sanchez, N, Stahl, Ea, Williams, S, Wray, Nr, Xia, K, Bettella, F, Borglum, Ad, Bulik Sullivan, Bk, Cormican, P, Craddock, N, Leeuw, De, C, Durmishi, N, Gill, M, Golimbet, V, Hamshere, Ml, Holmans, P, Hougaard, Dm, Kendler, Ks, Lin, K, Morris, Dw, Mors, O, Mortensen, Pb, Neale, Bm, O'Neill, Fa, Owen, Mj, Milovancevic, Mp, Posthuma, D, Powell, J, Richards, Al, Riley, Bp, Ruderfer, D, Rujescu, D, Sigurdsson, E, Silagadze, T, Smit, Ab, Stefansson, H, Steinberg, S, Suvisaari, J, Tosato, Sarah, Verhage, M, Walters, Jt, Multicenter Genetic Studies of Schizophrenia Consortium, Levinson, Df, Gejman, Pv, Laurent, C, Mowry, Bj, O'Donovan, Mc, Pulver, Ae, Schwab, Sg, Wildenauer, Db, Dudbridge, F, Shi, J, Albus, M, Alexander, M, Campion, D, Cohen, D, Dikeos, D, Duan, J, Eichhammer, P, Godard, S, Hansen, M, Lerer, Fb, Liang, Ky, Maier, W, Mallet, J, Nertney, Da, Nestadt, G, Norton, N, Papadimitriou, Gn, Ribble, R, Sanders, Ar, Silverman, Jm, Walsh, D, Williams, Nm, Wormley, B, Psychosis Endophenotypes International Consortium, Arranz, Mj, Bakker, S, Bender, S, Bramon, E, Collier, D, Crespo Facorro, B, Hall, J, Iyegbe, C, Jablensky, A, Kahn, Rs, Kalaydjieva, L, Lawrie, S, Lewis, Cm, Linszen, Dh, Mata, I, Mcintosh, A, Murray, Rm, Ophoff, Ra, Van, Os, J, Walshe, M, Weisbrod, M, Wiersma, D, Wellcome Trust Case Control Consortium 2, Donnelly, P, Barroso, I, Blackwell, Jm, Brown, Ma, Casas, Jp, Corvin, Ap, Deloukas, P, Duncanson, A, Jankowski, J, Markus, Hs, Mathew, Cg, Palmer, Cn, Plomin, R, Rautanen, A, Sawcer, Sj, Trembath, Rc, Viswanathan, Ac, Wood, Nw, Spencer, Cc, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, Rd, Strange, A, Su, Z, Vukcevic, D, Langford, C, Hunt, Se, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, Sj, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, Mccann, Ot, Liddle, J, Potter, Sc, Ravindrarajah, R, Ricketts, M, Tashakkori Ghanbaria, A, Waller, Mj, Weston, P, Widaa, S, Whittaker, P, Mccarthy, Mi, Stefansson, K, Scolnick, E, Purcell, S, Mccarroll, Sa, Sklar, P, Hultman, Cm, Sullivan, P. F.

Publikováno v: Nature Genetics, 45(10), 1150-1159. Nature Publishing Group
Ripke, S, O'Dushlaine, C, Chambert, K, Moran, J L, Kähler, A K, Akterin, S, Bergen, S E, Collins, A L, Crowley, J J, Fromer, M, Kim, Y, Lee, S H, Magnusson, P K, Sanchez, N, Stahl, E A, Williams, S, Wray, N R, Xia, K, Bettella, F, Borglum, A D, Bulik-Sullivan, B K, Cormican, P, Craddock, N, de Leeuw, C A, Durmishi, N, Gill, M, Golimbet, V, Hamshere, M L, Holmans, P, Hougaard, D M, Kendler, K S, Lin, K, Morris, D W, Mors, O, Mortensen, P B, Neale, B M, O'Neill, F A, Owen, M J, Milovancevic, M P, Posthuma, D, Powell, J, Richards, A L, Riley, B P, Ruderfer, D, Rujescu, D, Sigurdsson, E, Silagadze, T, Smit, A B, Stefansson, H, Steinberg, S, Suvisaari, J, Tosato, S, Verhage, M, Walters, T J, Levinson, D F, Gejman, P V, Laurent, C, Mowry, B J, O'Donovan, M C, Pulver, A E, Schwab, S G, Wildenauer, D B, Dudbridge, F, Shi, J, Albus, M, Alexander, M, Campion, D, Cohen, D, Dikeos, D, Duan, J, Eichhammer, P, Godard, S, Hansen, M, Lerer, F B, Liang, K Y, Maier, W, Mallet, J, Nertney, D A, Nestadt, G, Norton, N, O'Neill, F A, Papadimitriou, G N, Ribble, R, Sanders, A R, Silverman, J M, Wormley, B, Arranz, M J, Bakker, S, Bender, S, Bramon, E, Collier, D, Crespo-Facorro, B, Hall, J, Iyegbe, C, Jablensky, A, Kahn, R S, Kalaydjieva, L, Lawrie, S M, Lewis, C M, Linszen, D H, Mata, I, McIntosh, A, Murray, R M, Ophoff, R A, van Os, J, Walshe, M, Weisbrod, M, Wiersma, D, Donnely, P, Barasso, I, Blackwell, J M, Brown, M A, Casas, J P, Corvin, A P, Deloukas, P, Duncanson, A, Jankowski, J, Markus, H S, Mathew, C G, Palmer, C N, Plomin, R, Rautanen, A, Sawcer, S J, Trembath, R C, Viswanathan, A C, Wood, N W, Spencer, C C, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R D, Strange, A, Su, Z, Vukcevic, D, Langford, C, Hunt, S E, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, S, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, McCann, O T, Liddle, J, Potter, S C, Ravindrarajah, R, Ricketts, M, Tashakkori-Ghanbaria, A, Waller, M J, Weston, P, Widaa, S, Whittaker, P, Barrroso, I, McCarthy, M I, Spencer, C C, Stefansson, K, Scolnick, E, Purcell, S, McCarroll, S A, Sklar, P, Hultman, C M & Sullivan, P F 2013, ' Genome-wide association analysis identifies 13 new risk loci for schizophrenia ', Nature Genetics, vol. 45, no. 10, pp. 1150-1159 . https://doi.org/10.1038/ng.2742
Nature genetics, 45(10), 1150-1159. Nature Publishing Group
Nature Genetics, 45(10), 1150-U282. Nature Publishing Group
Ripke, S, O'Dushlaine, C, Chambert, K, Moran, J L, Kähler, A K, Akterin, S, Bergen, S E, Collins, A L, Crowley, J J, Fromer, M, Kim, Y, Lee, S H, Magnusson, P K E, Sanchez, N, Stahl, E A, Williams, S, Wray, N R, Xia, K, Bettella, F, Bulik-Sullivan, B K, Cormican, P, Craddock, N, de Leeuw, C, Durmishi, N, Gill, M, Golimbet, V, Hamshere, M L, Holmans, P, Hougaard, D M, Kendler, K S, Lin, K, Morris, D W, Mors, O, Mortensen, P B, Neale, B M, O'Neill, F A, Owen, M J, Milovancevic, M P, Posthuma, D, Powell, J, Richards, A L, Riley, B P, Ruderfer, D, Rujescu, D, Sigurdsson, E, Silagadze, T, Smit, A B, Stefansson, H, Steinberg, S, Børglum, A & Multicenter Genetic Studies of Schizophrenia Consortium 2013, ' Genome-wide association analysis identifies 13 new risk loci for schizophrenia ', Nature Genetics . https://doi.org/10.1038/ng.2742
Ripke, S, O'Dushlaine, C, Chambert, K, Moran, J L, Kähler, A K, Akterin, S, Bergen, S E, Collins, A L, Crowley, J J, Fromer, M, Kim, Y, Lee, S H, Magnusson, P K E, Sanchez, N, Stahl, E A, Williams, S, Wray, N R, Xia, K, Bettella, F, Borglum, A D, Bulik-Sullivan, B K, Cormican, P, Craddock, N, de Leeuw, C, Durmishi, N, Gill, M, Golimbet, V, Hamshere, M L, Holmans, P, Hougaard, D M, Kendler, K S, Lin, K, Morris, D W, Mors, O, Mortensen, P B, Neale, B M, O'Neill, F A, Owen, M J, Milovancevic, M P, Posthuma, D, Powell, J, Richards, A L, Riley, B P, Ruderfer, D, Rujescu, D, Sigurdsson, E, Silagadze, T, Hall, J & Lawrie, S & McIntosh, A 2013, ' Genome-wide association analysis identifies 13 new risk loci for schizophrenia ', Nature Genetics, vol. 45, no. 10, pp. 1150-9 . https://doi.org/10.1038/ng.2742

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ab6ab602c5351fa2e6cf88ebf1ab07
https://research.vu.nl/en/publications/6b6dbab0-5943-46a4-acf1-10e6003c769a

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