Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Autor: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P. Silverman, Thomas Wisniewski

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-33 (2022)

Abstract The increased life expectancy of individuals with Down syndrome (DS) is associated with increased prevalence of trisomy 21–linked early-onset Alzheimer’s disease (EOAD) and dementia. The aims of this study of 14 brain regions including t

Externí odkaz: https://doaj.org/article/e02fc323c41542f1af71ad39badabda8

Braak neurofibrillary tangle staging prediction from in vivo MRI metrics

Autor: Caroline Dallaire‐Théroux, Iman Beheshti, Olivier Potvin, Louis Dieumegarde, Stephan Saikali, Simon Duchesne, National Alzheimer's Coordinating Center, Alzheimer's Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 599-609 (2019)

Abstract Introduction Alzheimer's disease diagnosis requires postmortem visualization of amyloid and tau deposits. As brain atrophy can provide assessment of consequent neurodegeneration, our objective was to predict postmortem neurofibrillary tangle

Externí odkaz: https://doaj.org/article/6d690f599a544404adc9fb7e1589f536

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The probabilistic model of Alzheimer disease

Autor: Cornelia M. van Duijn, Philip Scheltens, Bruno Dubois, Jeffrey L. Cummings, Peter M. Nilsson, Rik Ossenkoppele, Rik van der Kant, Giovanni B. Frisoni, Pierre-Yves Dietrich, Daniele Altomare, Kaj Blennow, Dietmar Rudolf Thal, Federica Ribaldi

Publikováno v: Frisoni, G B, Altomare, D, Thal, D R, Ribaldi, F, van der Kant, R, Ossenkoppele, R, Blennow, K, Cummings, J, van Duijn, C, Nilsson, P M, Dietrich, P Y, Scheltens, P & Dubois, B 2022, ' The probabilistic model of Alzheimer disease: the amyloid hypothesis revised ', Nature Reviews Neuroscience, vol. 23, no. 1, pp. 53-66 . https://doi.org/10.1038/s41583-021-00533-w
Frisoni, G B, Altomare, D, Thal, D R, Ribaldi, F, van der Kant, R, Ossenkoppele, R, Blennow, K, Cummings, J, van Duijn, C, Nilsson, P M, Dietrich, P-Y, Scheltens, P & Dubois, B 2022, ' The probabilistic model of Alzheimer disease : the amyloid hypothesis revised ', Nature Reviews Neuroscience, vol. 23, no. 1, pp. 53-66 . https://doi.org/10.1038/s41583-021-00533-w
Nat Rev Neurosci

The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid deposition and then tau deposition to neurodegeneration and progressive cognitive impairment. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf61d409a9a66fc4416c0ec6e383285
http://www.scopus.com/inward/record.url?scp=85119834657&partnerID=8YFLogxK

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