Zobrazeno 1 - 10
of 317
pro vyhledávání: '"neuroepigenetics"'
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 95, Iss suppl 2 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons. Cases of ALS are classified as sporadic (sALS), or familial (f
Externí odkaz:
https://doaj.org/article/a87764f1498842899f7e9cfdb2ee1444
Autor:
Kwok Yui Tony Yip, Johannes Gräff
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram
Externí odkaz:
https://doaj.org/article/8282882283d6425ab74e6efa2b5a9a23
Autor:
María Araceli Ortiz-Rodríguez, María Fernanda Martínez-Salazar, Paola Kattyana Antunez-Bautista, Angélica Saraí Jiménez-Osorio
Publikováno v:
Aging and Health Research, Vol 3, Iss 1, Pp 100122- (2023)
Summary: The study of the biological mechanisms of aging is central to increasing knowledge about the susceptibility to the development of diseases associated with advanced age. The advancement of technology has allowed a greater understanding of the
Externí odkaz:
https://doaj.org/article/84523067adac472f90b9b9fb3e4864c5
Autor:
Salma Ferdous, Debresha A. Shelton, Tatiana E. Getz, Micah A. Chrenek, Nancy L’Hernault, Jana T. Sellers, Vivian R. Summers, P. Michael Iuvone, Jeremy M. Boss, Jeffrey H. Boatright, John M. Nickerson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
PurposeThe purpose of this study was to investigate the role of Lysine specific demethylase 1 (Lsd1) in murine retinal development. LSD1 is a histone demethylase that can demethylate mono- and di-methyl groups on H3K4 and H3K9. Using Chx10-Cre and Rh
Externí odkaz:
https://doaj.org/article/55c343cf7eea47fcbc3aafccb789a457
Publikováno v:
Cells, Vol 12, Iss 8, p 1179 (2023)
The Nucleosome Remodelling and Deacetylase (NuRD) complex represents one of the major chromatin remodelling complexes in mammalian cells, uniquely coupling the ability to “open” the chromatin by inducing nucleosome sliding with histone deacetylas
Externí odkaz:
https://doaj.org/article/508d23f1571346b7b2e9edaa19edbd41
Akademický článek
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Autor:
Elsher Lawson-Boyd, Maurizio Meloni
Publikováno v:
Frontiers in Human Neuroscience, Vol 15 (2021)
Epigenetics stands in a complex relationship to issues of sex and gender. As a scientific field, it has been heavily criticized for disproportionately targeting the maternal body and reproducing deterministic views of biological sex (Kenney and Müll
Externí odkaz:
https://doaj.org/article/a1dc0ae95516442b8e1546bf7ab5ecaa
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dysregulation of various component
Externí odkaz:
https://doaj.org/article/faaad56028474fe78efd312e7914a343
Autor:
Davide Martino Coda, Johannes Gräff
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Over the last two decades, the explosion of experimental, computational, and high-throughput technologies has led to critical insights into how the brain functions in health and disease. It has become increasingly clear that the vast majority of brai
Externí odkaz:
https://doaj.org/article/32efaba6e90246738db6e0853d1caa99
Autor:
Bhanu Chandra Karisetty, Akanksha Bhatnagar, Ellen M. Armour, Mariah Beaver, Haolin Zhang, Felice Elefant
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Amyloid-β (Aβ) peptides can form protease-resistant aggregates within and outside of neurons. Accumulation of these aggregates is a hallmark of Alzheimer’s disease (AD) neuropathology and contributes to devastating cognitive deficits associated w
Externí odkaz:
https://doaj.org/article/c66de044177f42048ee38cece75134e7