Výsledky vyhledávání - "neural progenitor cells (NPCs)"

Akademický článek

ARHGEF39, a Gene Implicated in Developmental Language Disorder, Activates RHOA and Is Involved in Cell De-Adhesion and Neural Progenitor Cell Proliferation

Autor: Midas Anijs, Paolo Devanna, Sonja C. Vernes

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

ARHGEF39 was previously implicated in developmental language disorder (DLD) via a functional polymorphism that can disrupt post-transcriptional regulation by microRNAs. ARHGEF39 is part of the family of Rho guanine nucleotide exchange factors (RhoGEF

Externí odkaz: https://doaj.org/article/7e584e8ceba347be83e3f19987bf2905

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Akademický článek

Selected Histone Deacetylase Inhibitors Reverse the Frataxin Transcriptional Defect in a Novel Friedreich’s Ataxia Induced Pluripotent Stem Cell-Derived Neuronal Reporter System

Autor: Anna M. Schreiber, Yanjie Li, Yi-Hsien Chen, Jill S. Napierala, Marek Napierala

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Friedreich’s ataxia (FRDA) is a neurodegenerative disorder caused by the expansion of guanine–adenine–adenine repeats within the first intron of the frataxin (FXN) gene. The location and nature of the expansion have been proven to contribute to

Externí odkaz: https://doaj.org/article/effb75e378d7492b82c21914c5234722

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Akademický článek

Robust Expression of Functional NMDA Receptors in Human Induced Pluripotent Stem Cell-Derived Neuronal Cultures Using an Accelerated Protocol

Autor: Jacob B. Ruden, Mrinalini Dixit, José C. Zepeda, Brad A. Grueter, Laura L. Dugan

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

N-methyl-D-aspartate (NMDA) receptors are critical for higher-order nervous system function, but in previously published protocols to convert human induced pluripotent stem cells (iPSCs) to mature neurons, functional NMDA receptors (NMDARs) are often

Externí odkaz: https://doaj.org/article/3cabc6151cc24a2b9af9c70870951f28

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Akademický článek

Human Brain Organoids to Decode Mechanisms of Microcephaly

Autor: Elke Gabriel, Anand Ramani, Nazlican Altinisik, Jay Gopalakrishnan

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early events of human brain development. Recent improvements with patient-specific 3D brain organoids have begun to elucidate unprecedented details of the defective m

Externí odkaz: https://doaj.org/article/a7bd891fede04150a9fb6ca4c7c1c425

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Akademický článek

The Antioxidant Phytochemical Schisandrin A Promotes Neural Cell Proliferation and Differentiation after Ischemic Brain Injury

Autor: Wentian Zong, Mostafa Gouda, Enli Cai, Ruofeng Wang, Weijie Xu, Yuming Wu, Paulo E. S. Munekata, José M. Lorenzo

Publikováno v: Molecules, Vol 26, Iss 24, p 7466 (2021)

Schisandrin A (SCH) is a natural bioactive phytonutrient that belongs to the lignan derivatives found in Schisandra chinensis fruit. This study aims to investigate the impact of SCH on promoting neural progenitor cell (NPC) regeneration for avoiding

Externí odkaz: https://doaj.org/article/df6cb3a7e96346ef9900666ab46cd840

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Akademický článek

Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex

Autor: Xuan Jiang, Xiao Dong, Shi-Hua Li, Yue-Peng Zhou, Simon Rayner, Hui-Min Xia, George F. Gao, Hui Yuan, Ya-Ping Tang, Min-Hua Luo

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Zika virus (ZIKV) infection is associated with severe neurological defects in fetuses and newborns, such as microcephaly. However, the underlying mechanisms remain to be elucidated. In this study, proteomic analysis on ZIKV-infected primary human fet

Externí odkaz: https://doaj.org/article/6765db6182c041859f9226902b4946d4

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BCL7A ‐containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation

Autor: Lena Wischhof, Hang‐Mao Lee, Janine Tutas, Clemens Overkott, Eileen Tedt, Miriam Stork, Michael Peitz, Oliver Brüstle, Thomas Ulas, Kristian Händler, Joachim L Schultze, Dan Ehninger, Pierluigi Nicotera, Paolo Salomoni, Daniele Bano

Publikováno v: The EMBO journal 41(23), e110595 (2022). doi:10.15252/embj.2022110595

Mammalian SWI/SNF/BAF chromatin remodeling complexes influence cell lineage determination. While the contribution of these complexes to neural progenitor cell (NPC) proliferation and differentiation has been reported, little is known about the transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95621f79e7a25d2198dd97f0003b94b2
https://doi.org/10.15252/embj.2022110595

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Gene Regulation Analysis Reveals Perturbations of Autism Spectrum Disorder during Neural System Development

Autor: Dan Li, Mary Qu Yang, Joshua Xu

Publikováno v: Genes
Genes, Vol 12, Iss 1901, p 1901 (2021)
Genes; Volume 12; Issue 12; Pages: 1901

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impedes patients’ cognition, social, speech and communication skills. ASD is highly heterogeneous with a variety of etiologies and clinical manifestations. The prevalence rate of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353333eeceef3897b05bef997e832303
http://europepmc.org/articles/PMC8700980

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