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Net Endogenous Acid Excretion and Kidney Allograft Outcomes

Autor: Stefan P Berger, Jan-Stephan F. Sanders, Martin H. de Borst, Gerjan Navis, Jenny E. Kootstra-Ros, Maryse C J Osté, Stanley M H Yeung, Else van den Berg, Juan Jesus Carrero, António W Gomes-Neto, Stephan J. L. Bakker

Publikováno v: Clinical Journal of the American Society of Nephrology, 16(9), 1398-1406. AMER SOC NEPHROLOGY
Clin J Am Soc Nephrol

BACKGROUND AND OBJECTIVES: High dietary acid load may accelerate a decline in kidney function. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients, and whether venous bicarbonate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec79d89f55f38464902f9d5a912566e
https://doi.org/10.2215/cjn.00780121

NBCn1 Increases NH4 + Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH4 + Excretion, and Early Recovery from Metabolic Acidosis

Autor: Jeppe Olsen, Vladimir V. Matchkov, Mads V. Sorensen, Ebbe Boedtkjer, Peder Berg, Vibeke Secher Dam, Samuel L Svendsen, Jens Leipziger

Publikováno v: Olsen, J S, Svendsen, S L S C, Berg, P, Dam, V S, Sørensen, M V, Matchkov, V, Leipziger, J G & Boedtkjer, E 2021, ' NBCn1 increases NH 4 + reabsorption across thick ascending limbs, the capacity for urinary NH 4 + excretion, and early recovery from metabolic acidosis ', Journal of the American Society of Nephrology, vol. 32, no. 4, pp. 852-865 . https://doi.org/10.1681/ASN.2019060613

BACKGROUND: The electroneutral Na +/HCO 3 - cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a835ca1be44c60d3cec5ac3b7546b56c
https://doi.org/10.1681/asn.2019060613

A marine teleost, Opsanus beta, compensates acidosis in hypersaline water by H+ excretion or reduced HCO3− excretion rather than HCO3− uptake

Autor: Kevin L. Schauer, Edward M. Mager, Zongli Yao, Ilan M. Ruhr, Rachael M. Heuer, Martin Grosell

Publikováno v: Journal of Comparative Physiology B. 191:85-98

Increases in ambient salinity demand parallel increases in intestinal base secretion for maintenance of osmoregulatory status, which is likely the cause of a transient acidosis following transfer of euryhaline fish from freshwater to seawater. It was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d74caca47c77dffce5ff1aa605f2eacf
https://doi.org/10.1007/s00360-020-01320-2

Uric acid stone disease: lessons from recent human physiologic studies

Autor: Triet Vincent M. Tran, Naim M. Maalouf

Publikováno v: Current Opinion in Nephrology & Hypertension. 29:407-413

Purpose of review An overly acidic urine resulting in supersaturation of urine with respect to uric acid is the major mechanism responsible for uric acid nephrolithiasis. The present review summarizes findings from recent human physiologic studies ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0754f460c477bf8a1c2777e0d8f9bdd
https://doi.org/10.1097/mnh.0000000000000610