Výsledky vyhledávání - "neonatal mice"

Akademický článek

Minocycline improves hippocampal neurogenetic defects in neonatal BTBR mice

Autor: LUO Yi, WANG Liuyongwei, ZHENG Fujie

Publikováno v: 陆军军医大学学报, Vol 45, Iss 22, Pp 2299-2309 (2023)

Objective To investigate the effects of minocycline(Mino) treatment on hippocampal neurogenesis in early post-life BTBR T+Itpr3tf /J (BTBR) autism model mice. Methods Healthy newborn C57BL/6J (C57) and BTBR male mice were randomly divided into 4 grou

Externí odkaz: https://doaj.org/article/ca3c0f4a515743f58ed20828fb6d4b35

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Akademický článek

PhoP/PhoQ Two-Component System Contributes to Intestinal Inflammation Induced by Cronobacter sakazakii in Neonatal Mice

Autor: Yan Ma, Yingying Zhang, Yuting Wang, Zhu Qiao, Yingying Liu, Xiaodong Xia

Publikováno v: Foods, Vol 13, Iss 17, p 2808 (2024)

Cronobacter sakazakii (C. sakazakii) is a foodborne pathogen capable of causing severe infections in newborns. The PhoP/PhoQ two-component system exerts a significant influence on bacterial virulence. This study aimed to investigate the impact of the

Externí odkaz: https://doaj.org/article/69bc545540df4ffeb0bb9ae91d5d39db

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Akademický článek

Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice

Autor: Imre Farkas, Katalin Skrapits, Miklós Sárvári, Balázs Göcz, Szabolcs Takács, Éva Rumpler, Erik Hrabovszky

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Reproduction in mammals is controlled by hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Recent studies from our laboratory established that the basal ganglia of the human brain contain additional large populations of GnRH synthesizing ne

Externí odkaz: https://doaj.org/article/64ef1f0af29b4a20910d65a6a3aa68fc

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Akademický článek

CRISPR-Cas9-mediated somatic correction of a one-base deletion in the Ugt1a gene ameliorates hyperbilirubinemia in Crigler-Najjar syndrome mice

Autor: Giulia Bortolussi, Alessandra Iaconcig, Giulia Canarutto, Fabiola Porro, Filippo Ferrucci, Claudia Galletta, Cristian Díaz-Muñoz, Vipin Rawat, Alessia De Caneva, Olayemi Joseph Olajide, Lorena Zentilin, Silvano Piazza, Luka Bočkor, Andrés Fernando Muro

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101161- (2023)

(AAV)-mediated episomal gene replacement therapy for monogenic liver disorders is currently limited in pediatric settings due to the loss of vector DNA, associated with hepatocyte duplication during liver growth. Genome editing is a promising strateg

Externí odkaz: https://doaj.org/article/c2f7c2a2a8134efd9f4b7723afb269fe

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Akademický článek

Lethality rescue and long-term amelioration of a citrullinemia type I mouse model by neonatal gene-targeting combined to SaCRISPR-Cas9

Autor: Michela Lisjak, Alessandra Iaconcig, Corrado Guarnaccia, Antonio Vicidomini, Laura Moretti, Fanny Collaud, Giuseppe Ronzitti, Lorena Zentilin, Andrés F. Muro

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101103- (2023)

Citrullinemia type I is a rare autosomal-recessive disorder caused by deficiency of argininosuccinate synthetase (ASS1). The clinical presentation includes the acute neonatal form, characterized by ammonia and citrulline accumulation in blood, which

Externí odkaz: https://doaj.org/article/a42a41ea318440d88db0d7c7e952dfc5

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Akademický článek

Targeted approaches to delineate neuronal morphology during early development

Autor: Bimin Liu, Yuxiao Li, Miao Ren, Xiangning Li

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Understanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at

Externí odkaz: https://doaj.org/article/670224f7f3194471863febad833c396b

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Akademický článek

Notch1 induces Th1/Th2 imbalance in neonatal mice with Streptococcus pneumoniae infection

Autor: WANG Yiying, JIAN Ding, ZHU Lin, ZHANG Hanzhi, LI Yuanyuan

Publikováno v: 陆军军医大学学报, Vol 44, Iss 21, Pp 2138-2145 (2022)

Objective To investigate the role of Notch1 signaling pathway in Th1/Th2 imbalance induced by neonatal Streptococcus pneumoniae pneumonia (S.pp) infection. Methods Twelve Balb/c neonatal mice (1 week old) were randomly divided into neonatal S.pp grou

Externí odkaz: https://doaj.org/article/9044597cf4f94c968daecac077144ce4

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Akademický článek

Robust Immune Response and Protection against Lethal Pneumococcal Challenge with a Recombinant BCG-PspA-PdT Prime/Boost Scheme Administered to Neonatal Mice

Autor: Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite

Publikováno v: Vaccines, Vol 12, Iss 2, p 122 (2024)

Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes

Externí odkaz: https://doaj.org/article/6e676a49476449608786d271faf919d6

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