Zobrazeno 1 - 10
of 327
pro vyhledávání: '"neoepitopes"'
Autor:
Gabrielle P. Dailey, Christopher A. Rabiola, Gangjun Lei, Junping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Melissa Gajda, Amy C. Hobeika, Amanda Summers, Robert D. Marek, Michael A. Morse, Herbert K. Lyerly, Erika J. Crosby, Zachary C. Hartman
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
ABSTRACTER+ breast cancers (BC) are characterized by the elevated expression and signaling of estrogen receptor alpha (ESR1), which renders them sensitive to anti-endocrine therapy. While these therapies are clinically effective, prolonged treatment
Externí odkaz:
https://doaj.org/article/e1e721b8aa614715a2839e38dfea6881
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Advancements in sequencing technologies and bioinformatics algorithms have expanded our ability to identify tumor-specific somatic mutation-derived antigens (neoantigens). While recent studies have shown neoantigens to be compelling targets for cance
Externí odkaz:
https://doaj.org/article/c1a582c62f694f479268c9411736f100
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101809- (2023)
Background: T1D is an autoimmune disease in which pancreatic islets of Langerhans are infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta cells. Our understanding of the factors leading to islet infiltrat
Externí odkaz:
https://doaj.org/article/739a8296cccc4b859cd972ef3d538867
Akademický článek
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Autor:
Xiangning Han, Hong Lin, Xiangfeng Chen, Luefeng Wang, Ziang Zhang, Xiaojing Wei, Xun Sun, Hanyi Xie, Tushar Ramesh Pavase, Limin Cao, Jianxin Sui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
For a long time, people have suffered from uncertainty, complexity, and a low success rate in generating and screening antibodies against small molecules, which have become the core bottlenecks of immunochemistry. Here, the influence of antigen prepa
Externí odkaz:
https://doaj.org/article/78bc5534ab624899b00ac758e882f093
Autor:
Annie Borch, Anne-Mette Bjerregaard, Vinicius Araujo Barbosa de Lima, Olga Østrup, Christina Westmose Yde, Aron Charles Eklund, Morten Mau-Sørensen, Carolina Barra, Inge Marie Svane, Finn Cilius Nielsen, Samuel A. Funt, Ulrik Lassen, Sine Reker Hadrup
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Immune checkpoint inhibition for the treatment of cancer has provided a breakthrough in oncology, and several new checkpoint inhibition pathways are currently being investigated regarding their potential to provide additional clinical benefit. Howeve
Externí odkaz:
https://doaj.org/article/0b564ce2af7e487693f9954c485f26ea
Autor:
Elisavet Vlachonikola, Nikolaos Pechlivanis, Georgios Karakatsoulis, Electra Sofou, Glykeria Gkoliou, Sabine Jeromin, Niki Stavroyianni, Pamela Ranghetti, Lydia Scarfo, Cecilia Österholm, Larry Mansouri, Sofia Notopoulou, Alexandra Siorenta, Achilles Anagnostopoulos, Paolo Ghia, Claudia Haferlach, Richard Rosenquist, Fotis Psomopoulos, Anastasia Kouvatsi, Panagiotis Baliakas, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMicroenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL pa
Externí odkaz:
https://doaj.org/article/f6260cb340aa4912a28e943471aebbb0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Posttranslational protein modifications (PTMs) are an inherent response to physiological changes causing altered protein structure and potentially modulating important biological functions of the modified protein. Besides cellular metabolic pathways
Externí odkaz:
https://doaj.org/article/f5a7a6abbaf644579de7ce0a3f15e0a4
Autor:
Aїsha Callebaut, Ylke Bruggeman, Cloé Zamit, Fernanda Marques Câmara Sodré, Magali Irla, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Post-translational modifications can lead to a break in immune tolerance in autoimmune diseases such as type 1 diabetes (T1D). Deamidation, the conversion of glutamine to glutamic acid by transglutaminase (TGM) enzymes, is a post-translational modifi
Externí odkaz:
https://doaj.org/article/2d1b545b8d42415fad5446261cee44bf
Autor:
Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz de Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos, Georgios D. Ayiomamitis
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-18 (2019)
Abstract Background Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune l
Externí odkaz:
https://doaj.org/article/b0bac254898046958b5ab4f0f7858e6a