Zobrazeno 1 - 10
of 501
pro vyhledávání: '"neoepitope"'
Autor:
Craig A. Vincent, Silvia Remeseiro
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1849-1852 (2024)
A first‐in‐human trial demonstrated that a vaccine targeting the histone mutation H3K27M can induce an immune response, in a mutation‐specific manner, in patients with diffuse midline glioma. In a recent study by Boschert et al., the same group
Externí odkaz:
https://doaj.org/article/7eb562fca33d4a7cb5338788b4dafa4f
Publikováno v:
Biomedical Journal, Vol 47, Iss 4, Pp 100729- (2024)
Idiopathic pulmonary fibrosis (IPF) diagnosis is still the diagnosis of exclusion. Differentiating from other forms of interstitial lung diseases (ILDs) is essential, given the various therapeutic approaches. The IPF course is now unpredictable for i
Externí odkaz:
https://doaj.org/article/cb1879e8070042e6b73f482bd6c56e43
Autor:
Annie Borch, Ibel Carri, Birkir Reynisson, Heli M. Garcia Alvarez, Kamilla K. Munk, Alessandro Montemurro, Nikolaj Pagh Kristensen, Siri A. Tvingsholm, Jeppe Sejerø Holm, Christina Heeke, Keith Henry Moss, Ulla Kring Hansen, Anna-Lisa Schaap-Johansen, Frederik Otzen Bagger, Vinicius Araujo Barbosa de Lima, Kristoffer S. Rohrberg, Samuel A. Funt, Marco Donia, Inge Marie Svane, Ulrik Lassen, Carolina Barra, Morten Nielsen, Sine Reker Hadrup
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMutation-derived neoantigens are critical targets for tumor rejection in cancer immunotherapy, and better tools for neoepitope identification and prediction are needed to improve neoepitope targeting strategies. Computational tools have ena
Externí odkaz:
https://doaj.org/article/0bbbca7628154c30a577b6a43214db8d
Autor:
Luiz Gustavo do Nascimento Rocha, Paul Anderson Souza Guimarães, Maria Gabriela Reis Carvalho, Jeronimo Conceição Ruiz
Publikováno v:
Vaccines, Vol 12, Iss 8, p 836 (2024)
Therapeutic cancer vaccines have been considered in recent decades as important immunotherapeutic strategies capable of leading to tumor regression. In the development of these vaccines, the identification of neoepitopes plays a critical role, and di
Externí odkaz:
https://doaj.org/article/eb62a869efbd408aa32175a1b6d69794
Autor:
Christopher Hackenbruch, Jens Bauer, Jonas S. Heitmann, Yacine Maringer, Annika Nelde, Monika Denk, Lisa Zieschang, Christine Kammer, Birgit Federmann, Susanne Jung, Peter Martus, Nisar P. Malek, Konstantin Nikolaou, Helmut R. Salih, Michael Bitzer, Juliane S. Walz
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The DNAJB1-PRKACA fusion transcript was identified as the oncogenic driver of tumor pathogenesis in fibrolamellar hepatocellular carcinoma (FL-HCC), also known as fibrolamellar carcinoma (FLC), as well as in other tumor entities, thus representing a
Externí odkaz:
https://doaj.org/article/a2dd1647213e47a0b299877dea3ea6f4
Autor:
Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Isabel Poschke, Michael Platten, Stefan Fröhling, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Dirk Jäger, Inka Zörnig, Frank Momburg
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity. To improve the discovery of T cell receptors (TCR) targeting neoantigens of indiv
Externí odkaz:
https://doaj.org/article/2562f0907ae7489481331f6d349419cb
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1063 (2024)
Pathological cleavage of type II collagen (Col2) and generation of Col2 neoepitopes can serve as useful molecular markers of the progression of osteoarthritis (OA). One of such potential biomarkers is type II collagen neoepitope C2C. The aim of this
Externí odkaz:
https://doaj.org/article/3959b5b9fb62416ba538558399bad6ab
Autor:
Ibel Carri, Erika Schwab, Enrique Podaza, Heli M. Garcia Alvarez, José Mordoh, Morten Nielsen, María Marcela Barrio
Publikováno v:
Exploration of Immunology, Vol 3, Iss 2, Pp 82-103 (2023)
In the last years, multiple efforts have been made to accurately predict neoantigens derived from somatic mutations in cancer patients, either to develop personalized therapeutic vaccines or to study immune responses after cancer immunotherapy. In th
Externí odkaz:
https://doaj.org/article/20a4ab5fe42740d892c2977300cc671e
Autor:
Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells. We had previously shown that
Externí odkaz:
https://doaj.org/article/8a24b0348b3c46f88fc706dfa5b638e0
Autor:
Yilin Ye, Yiming Shen, Jian Wang, Dong Li, Yu Zhu, Zhao Zhao, Youdong Pan, Yi Wang, Xing Liu, Ji Wan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5538-5543 (2023)
Target selection of the personalized cancer neoantigen vaccine, which is highly dependent on computational prediction algorithms, is crucial for its clinical efficacy. Due to the limited number of experimentally validated immunogenic neoepitopes as w
Externí odkaz:
https://doaj.org/article/907326f0d7d94a22a148a7aaa5877e16