Zobrazeno 1 - 10
of 2 879
pro vyhledávání: '"neoantigen"'
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Background Tumor Mutational Burden (TMB) have emerged as pivotal predictive biomarkers in determining prognosis and response to immunotherapy in colorectal cancer (CRC) patients. While Whole Exome Sequencing (WES) stands as the gold standard
Externí odkaz:
https://doaj.org/article/098433ab091a4fc4b4b3ca18a6bd4262
Autor:
Huiming Xia, My H. Hoang, Evelyn Schmidt, Susanna Kiwala, Joshua McMichael, Zachary L. Skidmore, Bryan Fisk, Jonathan J. Song, Jasreet Hundal, Thomas Mooney, Jason R. Walker, S. Peter Goedegebuure, Christopher A. Miller, William E. Gillanders, Obi L. Griffith, Malachi Griffith
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these th
Externí odkaz:
https://doaj.org/article/01d72c65e37e4a128cc544c775252cbb
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Mofan Feng, Liangjie Liu, Kai Su, Xianbin Su, Luming Meng, Zehua Guo, Dan Cao, Jiayi Wang, Guang He, Yi Shi
Publikováno v:
BMC Genomics, Vol 25, Iss S2, Pp 1-16 (2024)
Abstract Reliable and ultra-fast DNA and RNA sequencing have been achieved with the emergence of high-throughput sequencing technology. When combining the results of DNA and RNA sequencing for tumor cells of cancer patients, neoantigens that potentia
Externí odkaz:
https://doaj.org/article/043fca89c4d24e0ea85a89a96651c81c
Autor:
Wei Zheng, Shixiong Li, Zhongliang Shi, Kailing Su, Yu Ding, Luyue Zhang, Qian Tang, Jiani Han, Han Zhao, Fengwei Wang, Hongru Zhang, Zhangyong Hong
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors
Externí odkaz:
https://doaj.org/article/04cf4040c0c94dfba603e03929951722
Autor:
Xiaokun Zhang, Ye Wu, Jiayi Lin, Shengxin Lu, Xinchen Lu, Aoyu Cheng, Hongzhuan Chen, Weidong Zhang, Xin Luan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3818-3833 (2024)
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy. As vital biological mediators, peptides with high tissue penetration and superior selectivity offer significant promise for e
Externí odkaz:
https://doaj.org/article/4e96d6cb0559410681783ee1a600fbe2
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 205-212 (2024)
ABSTRACTIntroduction Clinical trials of personalized cancer vaccines have shown that on-demand therapies that are manufactured for each patient, result in activated T cell responses against individual tumor neoantigens. However, their use has been tr
Externí odkaz:
https://doaj.org/article/c49a5329643540508e3c44e5426a9e1f
Autor:
Xiaochuan Liu, Wen Jin, Dengyi Bao, Tongxin He, Wenhui Wang, Zekun Li, Xiaoxiao Yang, Yang Tong, Meng Shu, Yuting Wang, Jiapei Yuan, Yang Yang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2057-2066 (2024)
Intronic polyadenylation (IPA) refers to a particular type of alternative polyadenylation where a gene makes use of a polyadenylation site located within its introns. Aberrant IPA events have been observed in various types of cancer. IPA can produce
Externí odkaz:
https://doaj.org/article/4348de5adf884ea89ef5f54cd24c736f
Autor:
Yue Wang, Hanbing Wang, Tao Shi, Xueru Song, Xin Zhang, Yue Zhang, Xuan Wang, Keying Che, Yuting Luo, Lixia Yu, Baorui Liu, Jia Wei
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2170-2187 (2024)
Abstract The CLDN18-ARHGAP fusion gene is an oncogenic driver newly discovered in gastric cancer. It was detected in 9% (8/87) of gastric cancer patients in our center. An immunogenic peptide specifically targeting CLDN18-ARHGAP fusion gene was gener
Externí odkaz:
https://doaj.org/article/0f5c4a33287149c9a3c9e1183b00e088
Autor:
Tomohiro Yabushita, Yoshimitsu Shimomura, Hayato Maruoka, Daisuke Katoh, Daisuke Yamashita, Hironaga Satake, Nobuhiro Hiramoto, Satoshi Yoshioka, Noboru Yonetani, Momoko Nishikori, Takeshi Morimoto, Yukihiro Imai, Takayuki Ishikawa
Publikováno v:
eJHaem, Vol 5, Iss 4, Pp 698-708 (2024)
Abstract Somatic hypermutations (SHMs) in the variable region (VH) of the immunoglobulin heavy chain (IgH) gene are common in diffuse large B‐cell lymphoma (DLBCL). Recently, IgH VH SHMs have become known as immunogenic neoantigens, but few studies
Externí odkaz:
https://doaj.org/article/b22f7b1979c24583aac4b6c56dc70b75