Zobrazeno 1 - 10
of 10 181
pro vyhledávání: '"negative selection"'
Autor:
Szocik, Konrad
Publikováno v:
Feminist Bioethics in Space: Gender Inequality in Space Exploration.
Externí odkaz:
https://doi.org/10.1093/9780197691076.003.0005
Autor:
Daniel J. Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A. Haeusser, Bianca Walter, Adam Brown, Nicole S. Persky, David E. Root, Ghazaleh Tabatabai
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to uncover tumor-specific and common genetic dependencies across cancer cell lines. Current CRISPR-Cas9 knockout libraries, however, primarily target
Externí odkaz:
https://doaj.org/article/335008f1042a4c058cc57d3692251bc5
Autor:
Chao-Chao Li, Yi Bao, Ting Hou, Jia-Cui Li, Zhi-Yao Ma, Nan Wang, Xiao-Meng Wu, Kai-Dong Xie, Yong-Feng Zhou, Wen-Wu Guo
Publikováno v:
Horticulture Advances, Vol 2, Iss 1, Pp 1-14 (2024)
Abstract Chloroplast genomes, pivotal for understanding plant evolution, remain unexplored in Rutaceae, a family with key perennial crops like citrus. Leveraging next-generation sequencing data from 509 Rutaceae accessions across 15 species, we condu
Externí odkaz:
https://doaj.org/article/01b3548301bc4529a06085c2087cedf7
Autor:
Chan-Su Park, Jian Guan, Peter Rhee, Federico Gonzalez, Hee-sung Lee, Ji-hyun Park, Laurent Coscoy, Ellen A Robey, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 13 (2024)
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence s
Externí odkaz:
https://doaj.org/article/5dac43e64dda4b1c805566d173e337bf
Autor:
Beatriz de Carvalho Marques, Cecília Artico Banho, Lívia Sacchetto, Andreia Negri, Nikos Vasilakis, Maurício Lacerda Nogueira
Publikováno v:
Viruses, Vol 16, Iss 10, p 1524 (2024)
The high transmissibility, rapid evolution, and immune escape of SARS-CoV-2 variants can influence the course of infection and, in turn, morbidity and mortality in COVID-19, posing a challenge in controlling transmission rates and contributing to the
Externí odkaz:
https://doaj.org/article/14b9586cde994615957479841a07205a
Publikováno v:
HGG Advances, Vol 5, Iss 2, Pp 100262- (2024)
Summary: Widespread adoption of DNA sequencing has resulted in large numbers of genetic variants, whose contribution to disease is not easily determined. Although many types of variation are known to disrupt cellular processes in predictable ways, fo
Externí odkaz:
https://doaj.org/article/e48d4c242c734e6f969fb9231de37f5e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection. Their optimal ‘specificity’ level, i.e., probability of binding any par
Externí odkaz:
https://doaj.org/article/af6df0c92e9e4353bb4807749fa84229
Autor:
Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101171- (2024)
Chimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products. The first step, T cell selection, removes contamin
Externí odkaz:
https://doaj.org/article/e203f324125d46899b74298138fef026
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Selective constraint, the depletion of variation due to negative selection, provides insights into the functional impact of variants and disease mechanisms. However, its characterization in mice, the most commonly used mammalian m
Externí odkaz:
https://doaj.org/article/762c9a38a2e246febb013a106ca51c6c
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