Zobrazeno 1 - 10
of 262
pro vyhledávání: '"negative elongation-factor"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jiali Wang, Tianjiao Wang, Xiaoxing Guan, Jiayao Ou, Xue-Kun Guo, Rong Li, Xiaoyu Hu, Bin Zhang, Huji Xu
Publikováno v:
Mucosal Immunology. 15:279-288
Well-orchestrated transcriptional programs in intestinal epithelial cells (IECs) are essential for maintenance of optimal mucosal barrier functions, whereas the contribution of elongation-related mechanisms to barrier function remains unknown. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60de5f1d39ebea2347d119bf748f4a47
https://doi.org/10.1038/s41385-021-00465-9
https://doi.org/10.1038/s41385-021-00465-9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Feras E. Machour, Nabieh Ayoub
Publikováno v:
Trends in Genetics. 36:981-997
Defective double-strand break (DSB) repair leads to genomic instabilities that may augment carcinogenesis. DSBs trigger transient transcriptional silencing in the vicinity of transcriptionally active genes through multilayered processes instigated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b09c02d101e07b07894bcbeb154c8c
https://doi.org/10.1016/j.tig.2020.01.001
https://doi.org/10.1016/j.tig.2020.01.001
Publikováno v:
Genetics
Nagarkar, S, Wasnik, R, Govada, P, Cohen, S & Shashidhara, L S 2020, ' Promoter proximal pausing limits tumorous growth induced by the yki transcription factor in drosophila ', Genetics, vol. 216, no. 1, pp. 67-77 . https://doi.org/10.1534/genetics.120.303419
Nagarkar, S, Wasnik, R, Govada, P, Cohen, S & Shashidhara, L S 2020, ' Promoter proximal pausing limits tumorous growth induced by the yki transcription factor in drosophila ', Genetics, vol. 216, no. 1, pp. 67-77 . https://doi.org/10.1534/genetics.120.303419
Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebec06a08e7a0385055252d81274018d
https://doi.org/10.1534/genetics.120.303419
https://doi.org/10.1534/genetics.120.303419
Publikováno v:
Chinese Science Bulletin. 65:4084-4094
Transcriptional pausing is a widely used regulatory mechanism to control precise gene expression from bacteria to humans. In metazoans, transcription initiation requires the recruitment of general transcription factors and RNA polymerase II (Pol II)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b0c3dcd19b05feb1e6deabc2c576d1
https://doi.org/10.1360/tb-2020-0581
https://doi.org/10.1360/tb-2020-0581
Autor:
Ziyi Guo, Yingli Shang, Xiaomin Zeng, Bin Zhang, Inez Rogatsky, Dinesh K Deochand, David A. Rollins, Maddalena Coppo, Bowranigan Tharmalingam, Li Yu, Xiaoyu Hu, Maria A. Sacta, Yurii Chinenov, Rong Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Studies on macrophage gene expression have historically focused on events leading to RNA polymerase II recruitment and transcription initiation, whereas the contribution of post-initiation steps to macrophage activation remains poorly understood. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352cb49da695c638b5f11fc6ba586c21
https://doaj.org/article/b7a362703a864f72b486afd63dbb01f6
https://doaj.org/article/b7a362703a864f72b486afd63dbb01f6
Autor:
Prashant Rawat, Patrick Cramer, Fernando Aprile-Garcia, Anwit S. Pandit, Jorma J. Palvimo, Einari A. Niskanen, Seychelle M. Vos, Andrea Pichler, Marc Boehning, Barbara Hummel, Ashkan Khavaran, Nathalie Eisenhardt, Ritwick Sawarkar
Publikováno v:
Molecular Cell
Elsevier
Elsevier
Summary In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edd143eae28260a1af502230efbf14e
https://hdl.handle.net/21.11116/0000-0008-4C90-021.11116/0000-0008-4C9B-5
https://hdl.handle.net/21.11116/0000-0008-4C90-021.11116/0000-0008-4C9B-5
Publikováno v:
Molecular Cell. 81:896-898
In this issue of Molecular Cell, Rawat et al. (2021) characterize novel stress-induced condensates of the negative elongation factor (NELF) as the nuclear counterparts of cytosolic stress granules. This provides a new perspective on transcription rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7eeea5d32b95c7c419f7115b98fc61f
https://doi.org/10.1016/j.molcel.2021.02.008
https://doi.org/10.1016/j.molcel.2021.02.008