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pro vyhledávání: '"ndrg1"'
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Tongyue Yang, Qi Feng, Mingwei Shao, Mengxing Pan, Feng Guo, Yi Song, Fengjuan Huang, Zhao Linlin, Jiao Wang, Lina Wu, Guijun Qin, Yanyan Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Diabetic kidney disease (DKD) is characterized by complex pathogenesis and poor prognosis; therefore, an exploration of novel etiological factors may be beneficial. Despite glycemic control, the persistence of transient hyperglycemia still induces va
Externí odkaz:
https://doaj.org/article/7ca61470a6764da0859fd66d9516d88b
Autor:
Sukanya B. Jadhav, Michaela Vondrackova, Petra Potomova, Cristian Sandoval-Acuña, Jana Smigova, Kristyna Klanicova, Daniel Rosel, Jan Brabek, Jan Stursa, Lukas Werner, Jaroslav Truksa
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the exact role of NDRG1 remains controversial, as newer studies have shown that NDRG1 can also act
Externí odkaz:
https://doaj.org/article/babf7f9ee7ce45d2aa4ee3ab2d7ec896
Autor:
Isabel Mayayo‐Peralta, Donna O. Debets, Stefan Prekovic, Karianne Schuurman, Suzanne Beerthuijzen, Mathilde Almekinders, Joyce Sanders, Cathy B. Moelans, Sandra Saleiro, Jelle Wesseling, Paul J. vanDiest, Rui Henrique, Carmen Jerónimo, Maarten Altelaar, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 156-169 (2024)
Breast cancer (BCa) is a highly heterogeneous disease, with hormone receptor status being a key factor in patient prognostication and treatment decision‐making. The majority of primary tumours are positive for oestrogen receptor alpha (ERα), which
Externí odkaz:
https://doaj.org/article/729f177a629a4bda894d9576a75e0d22
Autor:
Derek Atkinson, Teodora Chamova, Ayse Candayan, Kristina Kastreva, Ognian Asenov, Ivan Litvinenko, Alejandro Estrada-Cuzcano, Els De Vriendt, Georgi Kukushev, Ivailo Tournev, Albena Jordanova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9047 (2024)
Charcot–Marie–Tooth neuropathy type 4D (CMT4D) is a rare genetic disorder of the peripheral nervous system caused by biallelic mutations in the N-Myc Downstream Regulated 1 gene (NDRG1). Patients present with an early onset demyelinating peripher
Externí odkaz:
https://doaj.org/article/f5493306513e415384662d4c19a0b064
Autor:
Vaibhavi Joshi, Andrew Stacey, Yufan Feng, Priyakshi Kalita‐de Croft, Pascal HG Duijf, Peter T Simpson, Sunil R Lakhani, Amy E McCart Reed
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract Brain metastases are secondary brain tumours characterised by their aggressive nature and poor prognosis. Breast cancer is one of the most common primary tumours in women to spread to the brain. A lack of biomarkers predicting likely spread
Externí odkaz:
https://doaj.org/article/2bd621ffce7f468c8b7dd6bbf721be3c
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background N-myc downstream-regulated gene-1 (NDRG1) is well-described as a potent metastasis suppressor, but its role in human breast cancer remains controversial and unclear. Therefore, the present study utilized a systematic review and me
Externí odkaz:
https://doaj.org/article/5d61b1cd0af94ca2a960d2f05a3997a4
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5585 (2024)
Anoikis, a form of apoptosis resulting from the loss of cell–extracellular matrix interaction, is a significant barrier to cancer cell metastasis. However, the epigenetic regulation of this process remains to be explored. Here, we demonstrate that
Externí odkaz:
https://doaj.org/article/dfb52612a8a4426e99af4bcb314a3a70
Autor:
Ermes Candiello, Gigliola Reato, Federica Verginelli, Gennaro Gambardella, Antonio D′Ambrosio, Noemi Calandra, Francesca Orzan, Antonella Iuliano, Raffaella Albano, Francesco Sassi, Paolo Luraghi, Paolo M. Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1280-1301 (2023)
In colorectal cancer, the mechanisms underlying tumor aggressiveness require further elucidation. Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem‐like cell cultures (m‐colospheres), here we show
Externí odkaz:
https://doaj.org/article/dc608abc77b544188c157027dd27b4aa