Anatomically-detailed segmented representative adult and pediatric nasal models for assessing regional drug delivery and bioequivalence with suspension nasal sprays.

Autor: Khadka P; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA., Hejazi M; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA., Hindle M; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA., Schuman T; Department of Otolaryngology - Head and Neck Surgery, VCU Health, Richmond, VA, USA., Longest W; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA., Kaviratna A; Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Chopski S; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Walenga R; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Newman B; Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Golshahi L; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: lgolshahi@vcu.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2024 Dec 05; Vol. 666, pp. 124743. Date of Electronic Publication: 2024 Sep 27.

Pharmacokinetic and Pharmacodynamic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults.

Autor: Greenhawt M; Section of Allergy and Immunology, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colo. Electronic address: Matthew.Greenhawt@childrenscolorado.org., Lieberman J; The University of Tennessee Health Science Center, Memphis, Tenn., Blaiss M; Department of Pediatrics, Medical College of Georgia, Augusta, Ga., Bernstein DI; Division of Immunology and Allergy, University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati, Ohio., Oppenheimer J; Department of Internal Medicine, University of Medicine and Dentistry of New Jersey-Rutgers New Jersey Medical School, Newark, NJ., DuBuske L; Department of Medicine, The George Washington University Hospital, Washington, DC., Fleischer D; Section of Allergy and Immunology, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colo., Dworaczyk DA; Bryn Pharma, LLC, Lebanon, NJ.

Publikováno v: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Dec; Vol. 12 (12), pp. 3274-3282.e2. Date of Electronic Publication: 2024 Oct 10.

Clinical efficacy and safety study of Loratadine combined with glucocorticoid nasal spray in the treatment of pediatric bronchial asthma with seasonal allergic rhinitis.

Autor: Yang H; Pharmacy center, Renmin Hospital, Hubei University of Medicine, Shiyan, China., Mao H; Dong Xin University, Naju-si, South Korea., Wang F; Department of Otolaryngology-Head and Neck Surgery, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China., Guo Q; Department of Otolaryngology-Head and Neck Surgery, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China., Chu J; Department of Otolaryngology-Head and Neck Surgery, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China., Zhao X; Department of Otolaryngology-Head and Neck Surgery, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China., Lei D; Department of Critical Care Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R.China.

Publikováno v: The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Dec; Vol. 61 (12), pp. 1698-1705. Date of Electronic Publication: 2024 Jul 31.

CFD-PK model for nasal suspension sprays: Validation with human adult in vivo data for triamcinolone acetonide.

Autor: Dutta R; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA., V Kolanjiyil A; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA., Walenga RL; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Chopski SG; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Kaviratna A; Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Mohan AR; Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Newman B; Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Golshahi L; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA., Longest W; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: pwlongest@vcu.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2024 Nov 15; Vol. 665, pp. 124660. Date of Electronic Publication: 2024 Sep 03.

A Prospective, Multicenter European Study on the Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms.

Autor: Manole F; Faculty of Medicine, Department of ENT, University of Oradea, Oradea, Romania., Hoermann K; Mannheim Medical Faculty, Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Germany., Passali D; IFOS Former President, ORL Head and Neck Surgery, University of Siena, Siena, Italy., Rombaux P; Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Maria Bellussi L; ENT Clinic, University of Siena, Siena, Italy., Rudenko M; Section of Allergy and Immunology, The London Allergy and Immunology Center, London, UK., Milkov M; Faculty of Dental Medicine, Medical University of Varna, Varna, Bulgaria., Kopacheva-Barsova G; ENT University Hospital, University Campus 'St. Mother Theresa' Skopje, Skopje, North Macedonia., Prokopakis E; Department of Otorhinolaryngology-Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Greece., Chabolle F; Department of Otolaryngology, Head, and Neck Surgery, Foch Hospital, Suresnes, France., Doulaptsi M; Department of Otorhinolaryngology-Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Greece., Bal C; Faculty of Medicine, Department of Biostatistics, Eskisehir Osmangazi University, Eskisehir, Turkey., Cingi C; Faculty of Medicine, Department of Otorhinolaryngology, Eskisehir Osmangazi University, Eskisehir, Turkey.

Publikováno v: Ear, nose, & throat journal [Ear Nose Throat J] 2024 Nov; Vol. 103 (3_suppl), pp. 168S-175S. Date of Electronic Publication: 2024 Nov 03.