Zobrazeno 1 - 10
of 850
pro vyhledávání: '"nAChRs"'
Autor:
Kevin M. Braunscheidel, George Voren, Christie D. Fowler, Qun Lu, Alexander Kuryatov, Michael D. Cameron, Ines Ibañez-Tallon, Jon M. Lindstrom, Theodore M. Kamenecka, Paul J. Kenny
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
BackgroundMost smokers attempting to quit will quickly relapse to tobacco use even when treated with the most efficacious smoking cessation agents currently available. This highlights the need to develop effective new smoking cessation medications. E
Externí odkaz:
https://doaj.org/article/13755185d072421ba960bb627e47c5e1
Autor:
SKV Manjari, Sharon Mariam Abraham, R. Poornima, Rajneesh Kumar Chaturvedi, Shuvadeep Maity, Pragya Komal
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp 116-125 (2023)
Introduction: 3-NP induction in rodent models has been shown to induce selective neurodegeneration in the striatum followed by the cortex (Brouillet, 2014). However, it remains unclear whether, under such a neurotoxic condition, characterized by neur
Externí odkaz:
https://doaj.org/article/d60081bd93a944d797eb0d05099382cc
Publikováno v:
International Journal of COPD, Vol Volume 18, Pp 2027-2038 (2023)
Gang Chen,1 Qing Mu,1 Zhao-Ji Meng2 1Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Immune Allerg
Externí odkaz:
https://doaj.org/article/864916029aed43628d325f1a12ad2c1b
Autor:
Yuanyuan Zhang, Hakim Hiel, Philippe F.Y. Vincent, Megan B. Wood, Ana B. Elgoyhen, Wade Chien, Amanda Lauer, Paul A. Fuchs
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 17-31 (2023)
Efferent brain-stem neurons release acetylcholine to desensitize cochlear hair cells and can protect the inner ear from acoustic trauma. That protection is absent from knockout mice lacking efferent inhibition and is stronger in mice with a gain-of-f
Externí odkaz:
https://doaj.org/article/a79bc30c2bc9499087ccecdc63b17e25
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106813- (2023)
The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the last decade, due to a) the improved techniques available for structural studies; b) the identification of ligands interacting at orthosteric and allosteric re
Externí odkaz:
https://doaj.org/article/65168e0769a145bcaacb7cc2d56dd8df
Publikováno v:
Experimental Gerontology, Vol 183, Iss , Pp 112318- (2023)
Sarcopenia involves in the loss of muscle mass associated with aging, which is the major cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a direct presentation of sarcopenia, and it greatly contributes to the
Externí odkaz:
https://doaj.org/article/143d0e14c6d44bf38bc89efb8024238f
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background As a human tumor disease, head and neck squamous cell carcinoma (HNSCC) is associated with a high mortality rate worldwide. Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptor proteins and exert their biological
Externí odkaz:
https://doaj.org/article/9fa3b4b67e584687842904d96c76f3a7
Autor:
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 118 (2024)
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investig
Externí odkaz:
https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499e
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