Zobrazeno 1 - 10
of 270
pro vyhledávání: '"n6-methyladenosine modification"'
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-37 (2024)
Abstract RNA splicing is a fundamental step of gene expression. While constitutive splicing removes introns and joins exons unbiasedly, alternative splicing (AS) selectively determines the assembly of exons and introns to generate RNA variants corres
Externí odkaz:
https://doaj.org/article/15ce628846914a96974c80d15632a932
Autor:
Ling Chen, Yanru Xiang, Shirong Zhong, Yinglin Wu, Jiaqi Liu, Yan Wu, Zhizhi Wang, Guodong Huang
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 10, Pp 1276-1283 (2024)
Objective(s): Ulcerative colitis (UC) is a commonly recurrent inflammatory bowel disease. T helper 17 (Th17)/regulatory T (Treg) cell balance plays an essential role in UC progression. However, it is unknown whether curcumin chitosan microspheres (CC
Externí odkaz:
https://doaj.org/article/076e5e8e91ee49c9a0e8b1ab32221275
Autor:
Zilin Tan, Liangjie Tian, Yang Luo, Kexin Ai, Xuehua Zhang, Haitao Yuan, Jinfan Zhou, Guangyao Ye, Shuofei Yang, Ming Zhong, Gaohua Li, Yanan Wang
Publikováno v:
Bioactive Materials, Vol 44, Iss , Pp 236-255 (2025)
Colorectal cancer (CRC) recurrence post-surgery remains a major challenge. While Chimeric Antigen Receptor (CAR)-engineered natural killer (NK) cells hold immense therapeutic potential, their intratumoral infiltration ability remains limited, hamperi
Externí odkaz:
https://doaj.org/article/8c14feec8a474790a1e702c2b275fdd9
Autor:
Quan Chen, Weijun Wan, Qing Zhao, Juan Li, Yanli Xiong, Yuchuan Yuan, Lu Tang, Xiaofeng Wu, Wei Xing, Wei Guo, Di Lu, Luoquan Ao, Xiang Xu, Xiang Ao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTo determine the role of N6-methyladenosine (m6A) modification in the tumor immune microenvironment (TIME), as well as their association with lung adenocarcinoma (LUAD).MethodsConsensus clustering was performed to identify the subgroups wit
Externí odkaz:
https://doaj.org/article/4cc2885ffc3b4bbd9c39c6398f59b9b0
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Background Acute kidney injury (AKI) is a frequent complication of severe acute pancreatitis (SAP). Previous investigations have revealed the involvement of FTO alpha-ketoglutarate-dependent dioxygenase (FTO) and aquaporin 3 (AQP3) in AKI. Therefore,
Externí odkaz:
https://doaj.org/article/164f10bde592449e824617ea3b8109d6
Publikováno v:
Zhongguo cuzhong zazhi, Vol 19, Iss 6, Pp 655-663 (2024)
目的 本研究通过探讨N6-甲基腺苷（N6-methyladenosine，m6A）修饰及其调控蛋白在脑缺血小鼠中的表达变化，为脑缺血治疗的分子靶点研究提供参考。 方法 取60只雄性C57BL/6J小鼠，随机分为假手
Externí odkaz:
https://doaj.org/article/f3b40327afff4a61a1bf0c836cb72c32
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background DNA N6-methyladenosine (6mA), as an important epigenetic modification, widely exists in bacterial genomes and participates in the regulation of toxicity, antibiotic resistance, and antioxidant. With the continuous development of s
Externí odkaz:
https://doaj.org/article/321b06223b7f48a899e0339ce6cc4861
Autor:
Min Yao, Zhirong Cheng, Xueyun Li, Yuexiang Li, Wei Ye, Hui Zhang, He Liu, Liang Zhang, Yingfeng Lei, Fanglin Zhang, Xin Lv
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate immunity. However, the role of m6A in regulating JEV replication has not been investigated. Here, we
Externí odkaz:
https://doaj.org/article/30658971105340f3a1f85a29c0613589
Autor:
Xiaohuang Lin, Jian Zhang, Zekai Wu, Yuan Shi, Mengting Chen, Maodong Li, Hong Hu, Kun Tian, Xiaoqi Lv, Chutao Li, Yang Liu, Xinyue Gao, Qiaomei Yang, Kunqi Chen, An Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacolog
Externí odkaz:
https://doaj.org/article/e64112f8d9d44a47aa52a3ec80da6ee4
Publikováno v:
Poultry Science, Vol 103, Iss 6, Pp 103671- (2024)
ABSTRACT: N6-methyladenosine (m6A) methylation in transcripts has been suggested to influence tumorigenesis in liver tumors caused by the avian leukosis virus subgroup J (ALV-J). However, m6A modifications during ALV-J infection in vitro remain uncle
Externí odkaz:
https://doaj.org/article/8aa8899b15b047d88fc666560ceff1e3