Zobrazeno 1 - 10
of 205
pro vyhledávání: '"n6-methyladenosine methylation"'
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Objective This study aims to identify m6A methylation-related and immune cell-related key genes with diagnostic potential for heart failure (HF) by leveraging various bioinformatics techniques. Methods The GSE116250 and GSE141910 datasets we
Externí odkaz:
https://doaj.org/article/c9324d363f534484876dd9e6ff2f94b3
Autor:
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102376- (2024)
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer patho
Externí odkaz:
https://doaj.org/article/da176ee8742f429abfdbe1de4a69633b
Autor:
Ye, Changzhou a, 1, Huang, Xuliang b, 1, Tong, Yao b, 1, Chen, Yating b, Zhao, Xinyu c, Xie, Wenjing d, Wang, Yuchen b, Wang, Junlu a, Zhang, Anqi a, ⁎, Mo, Yunchang a, ⁎
Publikováno v:
In International Immunopharmacology 10 January 2025 144
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repair. However, the spe
Externí odkaz:
https://doaj.org/article/5578a6a90e584129a6fa9ee60688fd41
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32455- (2024)
Long-time hypoxia induced cardiomyocyte apoptosis is an important mechanism of myocardial ischemia (MI) injury. Interestingly, long noncoding RNA myocardial infarction-associated transcript (LncMIAT) has been involved in the regulation of MI injury;
Externí odkaz:
https://doaj.org/article/db1e2bb266fc4a9cb7387577ef44ee00
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)
Abstract Background The biological behavior of low-grade glioma (LGG) is significantly affected by N6-methyladenosine (m6A) methylation, an essential epigenetic alteration. Therefore, it is crucial to create a prognostic model for LGG by utilizing ge
Externí odkaz:
https://doaj.org/article/b4a2a19dcec841f0b8270f5f6af56183
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-21 (2023)
Abstract Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in
Externí odkaz:
https://doaj.org/article/f3a8e2e65bde47ad87a020da9b0bba26
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-19 (2023)
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA methylation regulators, i.e., methyltransferases (“writers”), demethylases (
Externí odkaz:
https://doaj.org/article/13fd94afccbc48939c4b7aae4b70a2e3
Autor:
Shou-Yi Zhang, Yu Zeng
Publikováno v:
Asian Journal of Andrology, Vol 25, Iss 2, Pp 166-170 (2023)
N6-methyladenosine (m6A) is a ubiquitous RNA modification in mammals. This modification is “written” by methyltransferases and then “read” by m6A-binding proteins, followed by a series of regulation, such as alternative splicing, translation,
Externí odkaz:
https://doaj.org/article/0290e2171ff34a5995fe5dd3cb3166bd
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, maintaining mitochond
Externí odkaz:
https://doaj.org/article/f9e4e947403848feadd7441543ab10ab