Výsledky vyhledávání - "n-terminal kinase"

Akademický článek

Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury

Autor: Qunyan Chen, Jiachang Lao

Publikováno v: Journal of Physiological Investigation, Vol 67, Iss 4, Pp 174-186 (2024)

Sepsis is a syndrome of systemic inflammatory response resulting from infection, which can lead to severe lung injury. Histone deacetylase 4 (HDAC4) is a key protein known to regulate a wide range of cellular processes. This study was designed to inv

Externí odkaz: https://doaj.org/article/fd2bcc3c82cf451da9b4f169cc47fa1a

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Akademický článek

Mdivi-1 alleviates nicotine-induced human periodontal ligament cells injury by inhibiting mitochondrial fission and dysfunction through the JNK/Drp1 pathway

Autor: Leihua Cui, Meiqiao Chen, Yihong Jin, Huining Wang, Yubo Hou

Publikováno v: Ecotoxicology and Environmental Safety, Vol 288, Iss , Pp 117338- (2024)

Background: Nicotine, a major component of tobacco, is implicated in the pathogenesis of periodontitis. However, the exact mechanisms through which nicotine exerts its harmful effects remain incompletely understood. This study investigates the impact

Externí odkaz: https://doaj.org/article/da36ed8002a642e494615bfd8b56fd53

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Akademický článek

Evaluation of Taraxacum officinale phytoconstituents as potential JNK1 inhibitors: Perspectives from ADMET, molecular docking, molecular dynamics, and density functional theory

Autor: Sphelele C. Sosibo, Hendrik G. Kruger, Wonder P. Nxumalo, Zimbili Zondi

Publikováno v: Chemical Physics Impact, Vol 9, Iss , Pp 100757- (2024)

The impact of activated c-Jun N-terminal kinase isoform JNK1 chemical pathways in insulin biosynthesis poses a potential health risk of glucose intolerance. Blocking the activity of JNK1 is a promising route for the design of anti-diabetic drugs and

Externí odkaz: https://doaj.org/article/f523f9793c1f4d5db56cf82ae8915b77

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Akademický článek

Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells

Autor: Jing Zhang, Cui Li, Zhuo Chen, Xiaoling Zhao, Yuanyuan He, Lei Wei, Nana Kong

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 57 (2024)

Jun N-terminal kinase pathway-associated phosphatase (JKAP) regulates CD4+ T-cell differentiation and immunity, which are linked to mental disorders. This study aimed to explore the relationships between JKAP and T helper 17 (Th17)/regulatory T (Treg

Externí odkaz: https://doaj.org/article/772534bb4e2c4c5fb770c087a41400fb

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Akademický článek

Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway

Autor: Xin Liu, Wenjie Zhao, Man Hu, Yu Zhang, Jingcheng Wang, Liang Zhang

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 27, Iss 5, Pp 588-595 (2024)

Objective(s): Investigating the impact of cadmium (Cd) on annulus fibrosus (AF) cells and its potential mechanism was the purpose of the current study.Materials and Methods: Cd was cultivated in different concentrations (0, 1, 5, 10, and 20 μM) on A

Externí odkaz: https://doaj.org/article/2bea2917b32046aaa303075b94ce45e7

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Akademický článek

Inositol-requiring enzyme 1α and c-Jun N-terminal kinase axis activation contributes to intracellular lipid accumulation in calf hepatocytes

Autor: Wenwen Gao, Yanxi Wang, Siyu Liu, Guojin Li, Qi Shao, Cai Zhang, Liguang Cao, Kai Liu, Wenrui Gao, Zifeng Yang, Yifei Dong, Xiliang Du, Lin Lei, Guowen Liu, Xinwei Li

Publikováno v: Journal of Dairy Science, Vol 107, Iss 5, Pp 3127-3139 (2024)

ABSTRACT: During the perinatal period, dairy cows undergo negative energy balance, resulting in elevated circulating levels of nonesterified fatty acids (NEFA). Although increased blood NEFA concentrations are a physiological adaptation of early lact

Externí odkaz: https://doaj.org/article/0f2ff16940d14a75b1e1623d11f43490

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Akademický článek

Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-κB signaling after transient ischemic stroke in rats

Autor: Shang-Chih Huang, Hui-Chi Huang, Wen-Ling Liao, Shung-Te Kao, Chin-Yi Cheng

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

BackgroundGastrodia elata Blume, also called Tian Ma (TM), has been used to treat stroke for centuries. However, its effects on inflammation in acute cerebral ischemic injury and underlying mechanisms involved in microglial polarization remain unknow

Externí odkaz: https://doaj.org/article/534554f0a39642849e29df8850841f1e

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Akademický článek

The central role of mitochondrial metabolism in hepatic steatosis

Autor: Sanda Win, Tin Aung Than, Neil Kaplowitz, Nicole Wong, Aliza Arya, Zin Thandar Win, Shwe Hlaing Win, Ei Hnin Phyu, Christina Kuemerle, Jake Suh, Sona Avanesyan, Pujan Prakash Dobaria, Hnin Wai Lwin, Sean Wong, Shannon Kaw, Samuel Wong, Kyaw Khaing Soe, Garmani Kyaw, Filbert Win Min Aung

Publikováno v: Exploration of Digestive Diseases, Vol 3, Iss 1, Pp 42-68 (2024)

Mitochondria are present in all mammalian cells except matured red blood cells. Mitochondria consist of several metabolic pathways for glucose, fatty acids, amino acids, and bioenergetic pathways for ATP synthesis, membrane potential, and reactive ox

Externí odkaz: https://doaj.org/article/1ebf96b0fd424014ae0a8d147fd50ef5

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Akademický článek

Interleukin-1β activates matrix metalloproteinase-2 to alter lacrimal gland myoepithelial cell structure and function

Autor: Junji Morokuma, Angela Gárriz, Danny Toribio, Sarah Pagni, Driss Zoukhri

Publikováno v: Frontiers in Ophthalmology, Vol 4 (2024)

The aim of the present study is to investigate the role of c-Jun N-terminal kinase (JNK) and matrix metalloproteinase-2 (MMP-2) in mediating the effects of interleukin-1β (IL-1β) on the function of lacrimal gland myoepithelial cells (MECs). MECs is

Externí odkaz: https://doaj.org/article/ba2ae144cdd84af7a954db41482fc6c1

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