Variable phenotypes in individuals with grin2a sequence variants or deletions

Autor: Vlaskamp, D.R.M., Callenbach, P.M.C., Rump, P., Van Pinxteren-Nagler, E., Willemsen, M.H., Gunning, B., de Geus, C., Veenstra, Knol H.E., Lunsing, R.J., Dijkhuizen, T., Vos, Y.J., Brouwer, O.F., Van Ravenswaaij-Arts, C.M.A.

Publikováno v: Epilepsia, 57. Wiley

Purpose: The GRIN2A gene has been associated with epilepsies ranging from benign focal childhood epilepsies to severe epileptic encephalopathies. The aim of this study was to evaluate genotypes and phenotypes in individuals with GRIN2A deletions or v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::982bfe11849950d9b274155bf8c0cf02
https://research.rug.nl/en/publications/87f3764c-e1b2-4a9b-a193-64f3e087b6e2

Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations

Autor: Nikolay A. Bokhan, Nienke J. ter Woerds, P. Roberto Bakker, Maxim B. Freidin, Jim van Os, Olga Yu Fedorenko, Arkadiy V. Semke, Peter N. van Harten, Jacobus Brouwers, Svetlana A. Ivanova, Bob Wilffert, A. F. Y. Al Hadithy, Anton J. M. Loonen

Publikováno v: SAGE Open Medicine, Vol 4 (2016)
SAGE Open Medicine, 4:2050312116643673. SAGE Publications Inc.
SAGE Open Medicine
SAGE Open Medicine, 4, 1-9. SAGE Publications Inc.

Objectives: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a21dd97bfacb002d4e3324a1ffbfcd
https://doaj.org/article/167fc5058fec4776ad26b3a0956f3e6b

Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus

Autor: Tanya Comas, Geoffrey A.R. Mealing, Marzia Martina

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 4 (2013)

The hippocampus is a complex network tightly regulated by interactions between excitatory and inhibitory neurons. In neurodegenerative disorders where cognitive functions such as learning and memory are impaired this excitation-inhibition balance may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddb82e35113dbe90d2ba2f381bce0b7
http://europepmc.org/articles/PMC3595640

Expressions of N-methyl-D-aspartate receptors NR2A and NR2B subunit proteins in normal and sulfite-oxidase deficient rat's hippocampus: effect of exogenous sulfite ingestion

Autor: Zafer Yonden, Vural Kucukatay, Aysel Agar, Namik Delibas, Oktay Hasan Ozturk, Huseyin Bagci

Publikováno v: Archives of toxicology. 80(10)

Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30239815c50f599a5b938a922d5c755
https://pubmed.ncbi.nlm.nih.gov/16858610