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pro vyhledávání: '"myxovalargin"'
Akademický článek
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Autor:
Kösel, Teresa
The first part of this dissertation deals with the chemical total synthesis of peptide natural product Myxovalargin A, which was isolated from a culture supernatant of the myxobacterial strain Myxococcus fulvus, Mx f65, and first mentioned by name as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f76164fbb591a08ad3efe97932d5d28
https://www.repo.uni-hannover.de/handle/123456789/12430
https://www.repo.uni-hannover.de/handle/123456789/12430
Autor:
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. M. Boshoff, Bertrand Beckert, Joanna C. Evans, Jan Schlemmer, Becky Sloan, Danielle M. Weiner, Laura E. Via, Atica Moosa, Thomas R. Ioerger, Michael Graf, Boris Zinshteyn, Maha Abdelshahid, Fabian Nguyen, Stefan Arenz, Franziska Gille, Maik Siebke, Tim Seedorf, Oliver Plettenburg, Rachel Green, Anna-Luisa Warnke, Joachim Ullrich, Ralf Warrass, Clifton E. Barry, Digby F. Warner, Valerie Mizrahi, Andreas Kirschning, Daniel N. Wilson, Rolf Müller
Publikováno v:
Journal of the American Chemical Society.
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61df24b5a4b0bbef748e3d2b650186
https://pubmed.ncbi.nlm.nih.gov/36603206
https://pubmed.ncbi.nlm.nih.gov/36603206
Autor:
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. Boshoff, Bertrand Beckert, Joanna C. Evans, Jan Schlemmer, Becky Sloan, Danielle M. Weiner, Laura E. Via, Atica Moosa, Thomas R. Ioerger, Franziska Gille, Maik Siebke, Tim Seedorf, Oliver Plettenburg, Anna-Luisa Warnke, Joachim Ullrich, Ralf Warrass, Clifton E. Barry, Digby F. Warner, Valerie Mizrahi, Andreas Kirschning, Daniel N. Wilson, Rolf Müller
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f6c283c2b8195cb0e7617a3d4e5c55
https://doi.org/10.26434/chemrxiv-2022-vr3hn
https://doi.org/10.26434/chemrxiv-2022-vr3hn
Autor:
Siebke, Maik
Myxovalargin, ein lineares Peptid bestehend aus 14 Aminosäuren (AS), welches am C-Terminus mit 3-Methylbutansäure beginnt und am N-Terminus mit dem Amin Agmitin endet, wurde im Jahr 1981 aus dem Bakterium Myxococcus fulvus Mx f65 isoliert und entst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f1f2e260a02d149eb1243c8dca2b85
https://www.repo.uni-hannover.de/handle/123456789/11144
https://www.repo.uni-hannover.de/handle/123456789/11144
Akademický článek
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Autor:
Franziska Gille, Andreas Kirschning
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 564-570 (2016)
The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C–N cross-coupling protocol between an acyl amide and a
Externí odkaz:
https://doaj.org/article/a2456123212c4c29acde76268f04bce5
Autor:
Herbert Irschik, Hans Reichenbach
Publikováno v:
The Journal of antibiotics. 38(9)
Myxovalargin A has two modes of action. At low concentrations (below 1 microgram/ml) it inhibits bacterial protein synthesis specifically and instantaneously. In vitro experiments suggest that it interferes with the binding of aminoacyl tRNA to the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d25debc072443c07459bddf94c4c43
https://pubmed.ncbi.nlm.nih.gov/2415501
https://pubmed.ncbi.nlm.nih.gov/2415501
Autor:
Andreas Kirschning, Franziska Gille
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 564-570 (2016)
Beilstein Journal of Organic Chemistry 12 (2016)
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 564-570 (2016)
Beilstein Journal of Organic Chemistry 12 (2016)
The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C–N cross-coupling protocol between an acyl amide and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922ff553e0002296f018257194539a33
https://doi.org/10.3762/bjoc.12.55
https://doi.org/10.3762/bjoc.12.55