Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro.

Autor: Xu, Nanhui^1,2,3 (AUTHOR) 1191010006@fjtcm.edu.cn, Xie, Qiurong^1,2,3,4 (AUTHOR) 2020025@fjtcm.edu.cn, Chen, Youqin⁵ (AUTHOR) yxc571@case.edu, Li, Jiapeng⁶ (AUTHOR) 2009050@fjtcm.edu.cn, Zhang, Xiuli^1,2,3 (AUTHOR) 1201100007@fjtcm.edu.cn, Zheng, Huifang^1,2,3 (AUTHOR) c2020020@fjtcm.edu.cn, Cheng, Ying^1,2,3 (AUTHOR) 2181133010@fjtcm.edu.cn, Wu, Meizhu^1,2,3 (AUTHOR) 1211006008@fjtcm.edu.cn, Shen, Aling^1,2,3 (AUTHOR) 2018025@fjtcm.edu.cn, Wei, Lihui^1,2,3,4 (AUTHOR) weilihui@fjtcm.edu.cn, Yao, Mengying^1,2,3 (AUTHOR) 2201100021@fjtcm.edu.cn, Yang, Yanyan^1,2,3,4 (AUTHOR) 2011016@fjtcm.edu.cn, Sferra, Thomas J.⁵ (AUTHOR) thomas.sferra@uhhospitals.org, Jafri, Anjum⁵ (AUTHOR) axj21@case.edu, Fang, Yi^1,2,3,4 (AUTHOR) fy@fjtcm.edu.cn, Peng, Jun^1,2,3,4 (AUTHOR) fy@fjtcm.edu.cn

Publikováno v: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1200. 18p.

Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio)

Autor: Yi Liu, Xiaoling Shi, Chunjiao Lu, Guanhua Kou, Xuewei Wu, Xin Meng, Yuhang Lv, Juanjuan Luo, Wei Cui, Xiaojun Yang

Publikováno v: Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116976- (2024)

The accumulation of the active pharmaceutical chemical in the environment usually results in environmental pollution to increase the risk to human health. Indomethacin is a non-steroidal anti-inflammatory drug that potentially causes systemic and dev

Externí odkaz: https://doaj.org/article/9e8eacf86d104d359bd74f92ee318d59

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Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro

Autor: Nanhui Xu, Qiurong Xie, Youqin Chen, Jiapeng Li, Xiuli Zhang, Huifang Zheng, Ying Cheng, Meizhu Wu, Aling Shen, Lihui Wei, Mengying Yao, Yanyan Yang, Thomas J. Sferra, Anjum Jafri, Yi Fang, Jun Peng

Publikováno v: Pharmaceuticals, Vol 17, Iss 9, p 1200 (2024)

Gastrodin, a highly potent compound found in the traditional Chinese medicine Gastrodia elata Blume, exhibits significant antihypertensive properties. However, its role and the mechanism behind its protective effects on hypertensive cardiac condition

Externí odkaz: https://doaj.org/article/f8795ecbeb5746f592c4dc0c5c51c3c6

AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF-κB signaling pathway

Autor: Li, Zixuan, Yu, Zhili, Cui, Shengyu, Hu, Shan, Li, Bin, Chen, Tao, Qu, Chuan, Yang, Bo

Publikováno v: In International Immunopharmacology 30 May 2024 133