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Is Avoiding Stem Cell Exhaustion the New Therapeutic Approach in Colitis?

Autor: Anisa Shaker

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1204-1206 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7e2d6f725474d357ecdeaa0aacf2e2
http://www.sciencedirect.com/science/article/pii/S2352345X20302009

Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop

Autor: Timothy Chu, C. Benedikt Westphalen, Hans-Willem Snoeck, Haibo Liu, Hongxu Ding, Bernhard W. Renz, Theresa Swayne, Timothy C. Wang, Florence Borot, Michael Churchill, Siddhartha Mukherjee, Simon Renders, Karan Nagar, Daniel L. Worthley, Zhenyu Jiang, Pavel Tishchenko, Alexander L.E. Wang, Laura Munteanu, Andrea Califano, Ryota Takahashi, Moritz Middelhoff, Xing Du, Samuel Asfaha, Yoku Hayakawa, Yagnesh Tailor, Xiaowei Chen, Wenju Chang, Spandan V. Shah, Siu Hong Ho, Chyuan Sheng Lin, Zhengchuan Niu, Richard A. Friedman, Hongshan Wang, Larry L. Luchsinger, Huan Deng

Publikováno v: Paediatrics Publications

Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiesc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aacf519bd106c62483bc05a1dd01f80
https://pubmed.ncbi.nlm.nih.gov/29220661