Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

Autor: Juhye M Lee, Rachel Eguia, Seth J Zost, Saket Choudhary, Patrick C Wilson, Trevor Bedford, Terry Stevens-Ayers, Michael Boeckh, Aeron C Hurt, Seema S Lakdawala, Scott E Hensley, Jesse D Bloom

Publikováno v: eLife, Vol 8 (2019)

A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization b

Externí odkaz: https://doaj.org/article/2119b3de6f684d84a4356f027f1983d8

High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

Autor: Keara D. Malone, Christopher A. Cottrell, Thomas J. Ketas, Per Johan Klasse, John P. Moore, Sarah K Hilton, Jesse D. Bloom, Julie Overbaugh, Payal Pratap, Adam S. Dingens, Andrew B. Ward

Publikováno v: eLife
eLife, Vol 10 (2021)

Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbf10c8ead7c7d9c58d77ce74cb14f8
https://doi.org/10.7554/elife.64281

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

Autor: Saket Choudhary, Patrick C. Wilson, Aeron C. Hurt, Scott E. Hensley, Terry Stevens-Ayers, Seema S. Lakdawala, Juhye M. Lee, Trevor Bedford, Rachel Eguia, Jesse D. Bloom, Seth J. Zost, Michael Boeckh

Publikováno v: eLife, Vol 8 (2019)
eLife

A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dcd4de1c208d11bd980495f0f9ecd4
https://doi.org/10.1101/670497

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High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination.

Autor: Dingens AS; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Pratap P; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Malone K; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Hilton SK; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Ketas T; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Overbaugh J; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Moore JP; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States.; Howard Hughes Medical Institute, Seattle, United States.

Publikováno v: ELife [Elife] 2021 Jan 13; Vol. 10. Date of Electronic Publication: 2021 Jan 13.