Zobrazeno 1 - 10
of 43
pro vyhledávání: '"mutated huntingtin"'
Autor:
Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu, Tz-Chuen Ju
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-containing HTT pr
Externí odkaz:
https://doaj.org/article/f2d8f3d48b8b49b1a403ac4aecb9c14a
Autor:
Ryan Higgins, Marie-Helene Kabbaj, Delaney Sherwin, Lauren A. Howell, Alexa Hatcher, Robert J. Tomko, Jr., Yanchang Wang
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107898- (2020)
Summary: The accumulation of misfolded proteins is associated with multiple neurodegenerative disorders, but it remains poorly defined how this accumulation causes cytotoxicity. Here, we demonstrate that the Cdc48/p97 segregase machinery drives the c
Externí odkaz:
https://doaj.org/article/64665d8392944950b3c1f13929211b39
Autor:
Silvia Rea, David Della-Morte, Francesca Pacifici, Barbara Capuani, Donatella Pastore, Andrea Coppola, Roberto Arriga, Aikaterini Andreadi, Giulia Donadel, Nicola Di Daniele, Alfonso Bellia, Davide Lauro
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Patients with diabetes mellitus (DM) are more prone to develop cognitive decline and neurodegenerative diseases. A pathological association between an autosomal dominant neurological disorder caused by brain accumulation in mutated huntingtin (mHTT),
Externí odkaz:
https://doaj.org/article/c4d9183791e444b1ab49d9b2831f39bc
Akademický článek
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Autor:
Austin Folger, Yanchang Wang
Publikováno v:
Cells, Vol 10, Iss 11, p 2835 (2021)
Protein misfolding and aggregation are implicated in many neurodegenerative diseases. One of these diseases is Huntington’s, which is caused by increased glutamine-encoding trinucleotide repeats within the Huntingtin gene. Like other misfolded prot
Externí odkaz:
https://doaj.org/article/37ae36b92d884b0494124a943a5f326f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 1309, p 1309 (2021)
Journal of Personalized Medicine
Journal of Personalized Medicine
Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expansion (>35 copies) of a CAG triplet located in exon 1 of the HTT gene encoding the huntingtin protein (Htt). Mutated Htt (mHtt) easily aggregates, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29ddb8948ea113f829c317c76cd4595
http://hdl.handle.net/11573/1617233
http://hdl.handle.net/11573/1617233
Autor:
Robert J. Tomko, Ryan Higgins, Delaney Sherwin, Yanchang Wang, Alexa Hatcher, Lauren A. Howell, Marie-Helene Miquel Kabbaj
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107898-(2020)
Cell Rep
Cell Rep
Summary: The accumulation of misfolded proteins is associated with multiple neurodegenerative disorders, but it remains poorly defined how this accumulation causes cytotoxicity. Here, we demonstrate that the Cdc48/p97 segregase machinery drives the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48c65d6cb9606a3e8b91f52dbaffa57
http://www.sciencedirect.com/science/article/pii/S2211124720308792
http://www.sciencedirect.com/science/article/pii/S2211124720308792
Autor:
Sekáč, Dávid
Huntington's chorea is a dominantly inherited disease caused by trinucleotide (Cytosine-Adenine -Guanine) expansion in a gene coding huntingtin protein. Carriers of these mutation show symptoms associated with motor impairment, a cognitive and psychi
Externí odkaz:
http://www.nusl.cz/ntk/nusl-436405
Autor:
Sekáč, Dávid
Huntington's chorea is a dominantly inherited disease caused by trinucleotide (Cytosine-Adenine -Guanine) expansion in a gene coding huntingtin protein. Carriers of these mutation show symptoms associated with motor impairment, a cognitive and psychi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::459a517c34827ee4ee1a857ae0c8edc1
http://www.nusl.cz/ntk/nusl-436405
http://www.nusl.cz/ntk/nusl-436405