Zobrazeno 1 - 10
of 264
pro vyhledávání: '"multitargeting"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-38 (2024)
Abstract As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effectively reverse the root changes
Externí odkaz:
https://doaj.org/article/a0844420c9744b089727234a34b5fcdb
Autor:
Miaoliang Fan, Xiaoxin Song, Liwen Lu, Jiayan He, Yikai Shen, Changjun Zhang, Fang Wang, Yuanyuan Xie
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116786- (2024)
Multitargeting has become a promising strategy for the development of anti-Alzheimer's disease (AD) drugs, considering the complexity of molecular mechanisms in AD pathology. In most pre-clinical studies, the effectiveness of these multi-targeted ant
Externí odkaz:
https://doaj.org/article/b00aa50d9f5f467cab3e3fa11ecd88c1
Publikováno v:
Aggregate, Vol 5, Iss 1, Pp n/a-n/a (2024)
Abstract Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and serious complications, presenting a significant challenge to treat. Promising approaches for treating RA involve signaling pathways modulation and ta
Externí odkaz:
https://doaj.org/article/37182640121645688a6cb9a613fc1805
Autor:
Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal Venczel Szakács, Joachim Kirsch, Jochen Kuhse
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4165 (2024)
Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer’s disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD patholog
Externí odkaz:
https://doaj.org/article/776d3c059fd7494a818806c425716c96
Autor:
Antonio D’Errico, Rosarita Nasso, Rosario Rullo, Jessica Maiuolo, Paola Costanzo, Sonia Bonacci, Manuela Oliverio, Emmanuele De Vendittis, Mariorosario Masullo, Rosaria Arcone
Publikováno v:
Molecules, Vol 29, Iss 2, p 548 (2024)
Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds l
Externí odkaz:
https://doaj.org/article/00a40ae28811490dae91c142cf6fa954
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The two most common reasons for attrition in therapeutic clinical trials are efficacy and safety. We integrated heterogeneous data to create a human interactome network to comprehensively describe drug behavior in biological systems, with the goal of
Externí odkaz:
https://doaj.org/article/b02b200680cb41068d86deb5fdacbb82
Publikováno v:
MedComm – Future Medicine, Vol 2, Iss 1, Pp n/a-n/a (2023)
Abstract Cancer is one of the leading causes of death worldwide. The proliferation, survival, and metastasis of cancer cells are governed by a complex series of intracellular and extracellular signaling pathways. Therefore, efficient cancer therapy o
Externí odkaz:
https://doaj.org/article/564f35e6b7ef4aca8deb7ffbd6a7e40f
Autor:
Christine D. Hardy
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Antimicrobial resistance threatens our current standards of care for the treatment and prevention of infectious disease. Antibiotics that have multiple targets have a lower propensity for the development of antibiotic resistance than those t
Externí odkaz:
https://doaj.org/article/dae39fb7d3574179818ffb9ad6c43ac2