Zobrazeno 1 - 10
of 492
pro vyhledávání: '"multiplex immunohistochemistry"'
Autor:
Rongfang Shen, Ying Huang, Deyang Kong, Wenhui Ma, Jie Liu, Haizeng Zhang, Shujun Cheng, Lin Feng
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The spatial context of tumor-infiltrating immune cells (TIICs) is important in predicting colorectal cancer (CRC) patients’ clinical outcomes. However, the prognostic value of the TIIC spatial distribution is unknown. Thus, we a
Externí odkaz:
https://doaj.org/article/3ac5f1887ec748c09312629758d4e978
Autor:
Justus Kaufmann, Maximilian Haist, Ivan-Maximiliano Kur, Stefanie Zimmer, Jan Hagemann, Christoph Matthias, Stephan Grabbe, Heinz Schmidberger, Andreas Weigert, Arnulf Mayer
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 102019- (2024)
The growth pattern of oropharyngeal squamous cell carcinomas (OPSCC) varies from compact tumor cell aggregates to diffusely infiltrating tumor cell-clusters. The influence of the growth pattern on local tumor control and survival has been studied mai
Externí odkaz:
https://doaj.org/article/00464a0c31cb415aa53bf4a1c2be142f
Autor:
Jiangong Zhang, Qinqin Zhu, Xun Shi, Yang Huang, Linlin Yan, Guozheng Zhang, Lei Pei, Jiahuan Liu, Xiaowei Han, Xisong Zhu
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32800- (2024)
Cognitive impairment is an important component of non motor symptoms in Parkinson's disease (PD), and if not addressed in a timely manner, it can easily progress to dementia. However, no effective method currently exists to completely prevent or reve
Externí odkaz:
https://doaj.org/article/99c59f8569aa4417b85dd5cfca41b1cc
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionNucleic acid-sensing (NAS) pathways could induce innate and adaptive immune responses. However, rare evidence exhibited how the core genes of the NAS pathways affected the immune response and prognosis of small cell lung cancer (SCLC) pat
Externí odkaz:
https://doaj.org/article/369820044e5a4f5b9b5b3c9389b48f27
Autor:
Cadri Knoch, Veronika Baghin, Patrick Turko, Nicola Winkelbeiner, Ramon Staeger, Kongchang Wei, Irina Banzola, Mark Mellett, Mitchell P. Levesque, Thomas Kuendig, Lars E. French, Lucie Heinzerling, Barbara Meier-Schiesser
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9720 (2024)
Lichen planus (LP) is a highly prevalent inflammatory skin disease. While various clinical subtypes have been defined, detailed comparisons of these variants are lacking. This study aimed to elucidate differences in gene expression and cellular compo
Externí odkaz:
https://doaj.org/article/41ad2905c7db4589ba660685a7bf991b
Autor:
Ayaka Asakawa, Ryoto Yoshimoto, Maki Kobayashi, Nanae Izumi, Takanori Maejima, Tsuneo Deguchi, Kazuishi Kubota, Hisashi Takahashi, Miyuki Yamada, Sachiko Ishibashi, Iichiroh Onishi, Yuko Kinowaki, Morito Kurata, Masashi Kobayashi, Hironori Ishibashi, Kenichi Okubo, Kenichi Ohashi, Masanobu Kitagawa, Kouhei Yamamoto
Publikováno v:
Cancers, Vol 16, Iss 11, p 2140 (2024)
Lung squamous cell carcinoma (LSCC) is refractory to various therapies for non-small cell cancer; therefore, new therapeutic approaches are required to improve the prognosis of LSCC. Although immunotherapies targeting B7 family molecules were explore
Externí odkaz:
https://doaj.org/article/a210ea492d8845d19080dcdbf023ee8b
Autor:
Brian D. Griffith, Jenny Lazarus, Jake McGue, Santhoshi Krishnan, Michael I. D’Angelica, Jinru Shia, Irina Dobrosotskaya, Jaiqi Shi, Jacob Edwards, Arvind Rao, Timothy L. Frankel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMetastatic colorectal cancer (mCRC) remains a common and highly morbid disease, with a recent increase in incidence in patients younger than 50 years. There is an acute need to better understand differences in tumor biology, molecular cha
Externí odkaz:
https://doaj.org/article/ed68ae9a295e4cebb8bc43b4e0482043
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e21062- (2023)
Background: Gastric cancer (GC) ranks third in terms of mortality worldwide. The tumor microenvironment is critical for the progression of gastric cancer. This study investigated the association between EF-hand domain containing 1 (EFHD1) expression
Externí odkaz:
https://doaj.org/article/e565f77bea7145728bf1ca193fa19c07
Autor:
Hanyun Zhang, Khalid AbdulJabbar, Tami Grunewald, Ayse U. Akarca, Yeman Hagos, Faranak Sobhani, Catherine S.Y. Lecat, Dominic Patel, Lydia Lee, Manuel Rodriguez-Justo, Kwee Yong, Jonathan A. Ledermann, John Le Quesne, E. Shelley Hwang, Teresa Marafioti, Yinyin Yuan
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104769- (2023)
Summary: Background: Efficient biomarker discovery and clinical translation depend on the fast and accurate analytical output from crucial technologies such as multiplex imaging. However, reliable cell classification often requires extensive annotati
Externí odkaz:
https://doaj.org/article/247dba90151c4cdeb67c905958d7c6d9
Autor:
Chunbin Zhu, Jiaqiang Ma, Kai Zhu, Lei Yu, Bohao Zheng, Dongning Rao, Shu Zhang, Liangqing Dong, Qiang Gao, Xiaoming Zhang, Diyang Xie
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100762- (2023)
Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) is a severe malignant tumour that shows only modest responses to immunotherapy. We aimed to identify the spatial immunophenotypes of iCCA and delineate potential immune escape mechanisms. Meth
Externí odkaz:
https://doaj.org/article/f654bb256f534edeb81a5051b62f2baf