Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies

Autor: Rouyan Chen, Jasmine Sarah Pye, Jiarong Li, Christopher B. Little, Jiao Jiao Li

Publikováno v: Bioactive Materials, Vol 27, Iss , Pp 505-545 (2023)

Osteochondral defects are caused by injury to both the articular cartilage and subchondral bone within skeletal joints. They can lead to irreversible joint damage and increase the risk of progression to osteoarthritis. Current treatments for osteocho

Externí odkaz: https://doaj.org/article/7118f55364694ecfab0a760139eccbc8

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A Graded, Porous Composite of Natural Biopolymers and Octacalcium Phosphate Guides Osteochondral Differentiation of Stem Cells

Autor: Elisabeth Amann, Elizabeth R. Balmayor, Isabel B. Leonor, Gastón Fuentes Estévez, Martijn van Griensven, Amisel Amirall, Rui L. Reis, Francisco J. Sola Dueñas, Patrina S. P. Poh, Albina R. Franco

Publikováno v: Advanced Healthcare Materials, 10(6):2001692. Wiley
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Lesions involving the osteochondral unit are difficult to treat. Biomimetic scaffolds are previously shown as promising alternative. Such devices often lack multiple functional layers that mimic bone, cartilage, and the interface. In this study, mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6edfa11aed618c5cd169124d71252c
https://doi.org/10.1002/adhm.202001692

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Multiphasic, multistructured and hierarchical strategies for cartilage regeneration

Autor: Correia, Clara R., Reis, R. L., Mano, J. F.

Cartilage tissue is a complex nonlinear, viscoelastic, anisotropic, and multiphasic material with a very low coefficient of friction, which allows to withstand millions of cycles of joint loading over decades of wear. Upon damage, cartilage tissue ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______307::d46d147e41c9032c2db0d6e764890557
https://hdl.handle.net/1822/40336