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Interplay between Lipids and Complement Proteins-How Multiomics Data Integration Can Help Unravel Age-related Macular Degeneration Pathophysiology: A Proof-of-concept Study.

Autor: Nusinovici S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Zhou L; Department of Applied Biology and Chemical Technology, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.; Agency for Science, Technology and Research (A∗STAR), Institute of Molecular and Cell Biology, Singapore, Singapore., Raghavan L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Li H; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Cheung D; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wang X; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Agency for Science, Technology and Research (A∗STAR), Institute of Molecular and Cell Biology, Singapore, Singapore., Cheung CMG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Tsinghua Medicine, Tsinghua University, Beijing, China., Chakravarthy U; Queen's University of Belfast, Belfast, United Kingdom., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Publikováno v: Ophthalmology science [Ophthalmol Sci] 2024 Oct 01; Vol. 5 (1), pp. 100629. Date of Electronic Publication: 2024 Oct 01 (Print Publication: 2025).

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Multiomics data integration to reveal chromatin remodeling and reorganization induced by gene mutational synergy

Autor: Haiyang Yun, Shabana Vohra, David Lara-Astiaso, Brian J.P. Huntly

Publikováno v: STAR Protocols, Vol 3, Iss 4, Pp 101770- (2022)

Summary: Recurrent gene mutations often cooperate in a predefined stepwise and synergistic manner to alter global transcription, through directly or indirectly remodeling epigenetic landscape on linear and three-dimensional (3D) scales. Here, we pres

Externí odkaz: https://doaj.org/article/0d755c75cfb44d0181e7fd5ef22661e0