Zobrazeno 1 - 10
of 188
pro vyhledávání: '"multifunctional ligands"'
Publikováno v:
Farmacja Polska, Vol 79, Iss 12, Pp 789-800 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder. Although the first case of Alzheimer’s disease was recorded over a century ago, the etiology of the disease remains unknown. There are several hypotheses regarding the process of neurodege
Externí odkaz:
https://doaj.org/article/452bebf2419e4139a0ae076147cd942a
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Autor:
Kristen H. Scherrer, Shainnel O. Eans, Jessica M. Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1218 (2023)
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated
Externí odkaz:
https://doaj.org/article/e7827524f44543a88550968c9e396464
Autor:
Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5
Publikováno v:
Molecules, Vol 27, Iss 24, p 8785 (2022)
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs. Prescription
Externí odkaz:
https://doaj.org/article/9931d7c9ca14407e88471dc1a03c3718
Publikováno v:
Molecules, Vol 26, Iss 14, p 4118 (2021)
The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreve
Externí odkaz:
https://doaj.org/article/bd6600801b8b4baaafe52a4747ceaf25
Autor:
Gruden, Staš
Alzheimerjeva bolezen (AB) je večfunkcionalna nevrodegenerativna bolezen, kjer poleg upada holinergičnega prenosa pride tudi do motenj v delovanju noradrenergičnega sistema v možganih. Pri napredovani obliki AB se poveča aktivnost butirilholin e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3505::83dab2cd8ae299ea704313cef7ad979c
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145715
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145715
Autor:
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Molecules, Vol 25, Iss 17, p 3999 (2020)
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues’ stereochemistry on
Externí odkaz:
https://doaj.org/article/017a586349384007872af65cadb6d478
Autor:
Anja Pišlar, Anna Więckowska, Barbara Malawska, Paula Zaręba, Raimon Sabaté, Dawid Panek, Jakub Jończyk, Tomasz Wichur, Natalia Szałaj, Anna Pasieka, Krzysztof Więckowski, Justyna Godyń, Marek Bajda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605fad8a83670327e0c22e4f705ac0bf
https://doi.org/10.1080/14756366.2020.1835882
https://doi.org/10.1080/14756366.2020.1835882
Autor:
Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9443
Neurodegeneration leading to Alzheimer’s disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8815f709e03fedba13439d619bcb7fcc