Výsledky vyhledávání - "multifunctional CD8 T cells"

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Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8⁺ T cells.

Autor: Shu Wang¹, Campos, Jose¹, Gallotta, Marilena¹, Mei Gong¹, Crain, Chad¹, Naik, Edwina¹, Coffman, Robert L.¹, Guiducci, Cristiana¹

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 11/15/2016, Vol. 113 Issue 46, pE7240-E7249. 10p.

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Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells

Autor: Cristiana Guiducci, Edwina Naik, Mei Gong, José L. Campos, Shu Wang, Chad Crain, Robert L. Coffman, Marilena Gallotta

Despite the impressive rates of clinical response to programmed death 1 (PD-1) blockade in multiple cancers, the majority of patients still fail to respond to this therapy. The CT26 tumor in mice showed similar heterogeneity, with most tumors unaffec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0bc44dbc8369d7dfe994a1af826121
https://europepmc.org/articles/PMC5135381/

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Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

Autor: Claire Jones, Monica A. McArthur, Laurence S. Magder, Christoph J. Blohmke, Myron M. Levine, Andrew J. Pollard, Thomas C. Darton, Marcelo B. Sztein, Stephanie Fresnay, Brian Angus, Claire S. Waddington

Publikováno v: Journal of Translational Medicine

Background Typhoid fever, caused by the human-restricted organism Salmonella Typhi (S. Typhi), is a major public health problem worldwide. Development of novel vaccines remains imperative, but is hampered by an incomplete understanding of the immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9bf196634c225e49f766204b57fed6
https://pubmed.ncbi.nlm.nih.gov/26928826

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Cytotoxic CD8+ T Cells Expressing CXCR5 Are Detectable in HIV-1 Elite Controllers After Prolonged In Vitro Peptide Stimulation

Autor: Philipp Adams, Gilles Iserentant, Jean-Yves Servais, Linos Vandekerckhove, Guido Vanham, Carole Seguin-Devaux, the PhenoCure Study Group

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Antiretroviral therapy (ART) is not curative as HIV-1 persists in long-lived viral reservoirs. Consequently, patients are dependent on life-long drug adherence with possible side effects. To overcome these limitations strategies of a functional cure

Externí odkaz: https://doaj.org/article/2539b03dba354e79b24b2c8006d41d67

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Akademický článek

AIM2 co-immunization favors specific multifunctional CD8+ T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis

Autor: Chai, Dafei, Yue, Yan, Xu, Wei, Dong, Chunsheng, Xiong, Sidong ^⁎

Publikováno v: In Antiviral Research July 2015 119:68-77

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Therapeutic Adenovirus Vaccine Combined Immunization with IL-12 Induces Potent CD8+ T Cell Anti-Tumor Immunity in Hepatocellular Carcinoma

Autor: Yanyan Zheng, Zheng Lu, Jiage Ding, Nan Jiang, Jiawei Wang, Jie Yang, Jingyuan Song, Hongliang Chen, Lin Fang, Huizhong Li, Hui Tian, Gang Wang, Junnian Zheng, Dafei Chai

Publikováno v: Cancers; Volume 14; Issue 18; Pages: 4512

Hepatocellular carcinoma (HCC) is one of the cancers with the highest morbidity and mortality in the world. However, clinical progress in the treatment of HCC has not shown a satisfactory therapeutic effect. Here, we have developed a novel strategy t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6cff112cd6ba28cde55e7f7c216f21
https://doi.org/10.3390/cancers14184512

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