The PRIMED Consortium: Reducing disparities in polygenic risk assessment.

Autor: Kullo IJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: kullo.iftikhar@mayo.edu., Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Adebamowo SN; Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, USA., Choudhury A; Sydney Brenner Institute of Molecular Bioscience, University of Witwatersrand, Johannesburg, South Africa., Conti D; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Fullerton SM; Department of Bioethics and Humanities, University of Washington School of Medicine, Seattle, WA, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Heavner B; Department of Biostatistics, University of Washington, Seattle, WA, USA., Hornsby WE; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kenny EE; Institute of Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Khan A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Khera AV; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Li Y; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Martin I; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA., Mercader JM; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ng M; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raffield LM; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Reiner A; Department of Epidemiology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Rowley R; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA., Schaid D; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Stilp A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wiley K; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA., Wilson R; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA., Witte JS; Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA., Natarajan P; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2024 Dec 05; Vol. 111 (12), pp. 2594-2606. Date of Electronic Publication: 2024 Nov 18.

Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores.

Autor: Zhong W; Department of Obstetrics and Gynecology, The Seventh Medical Center of People's Liberation Army General Hospital, Beijing, China.; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China.; Department of Obstetrics and Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China., Wang Q; Department of Obstetrics and Gynecology, The Seventh Medical Center of People's Liberation Army General Hospital, Beijing, China., Peng D; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China., Zou Y; Department of Clinical Research, Yikon Genomics Co., Ltd, Suzhou, Jiangsu, China., Chen Y; Department of Clinical Research, Yikon Genomics Co., Ltd, Suzhou, Jiangsu, China., Xia Y; Department of Clinical Research, Yikon Genomics Co., Ltd, Suzhou, Jiangsu, China., Zhang X; Department of Clinical Research, Yikon Genomics Co., Ltd, Suzhou, Jiangsu, China., Shu M; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China., Song C; Department of Obstetrics and Gynecology, The Seventh Medical Center of People's Liberation Army General Hospital, Beijing, China., Wang Y; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China., Fu Y; Department of Obstetrics and Gynecology, Chinese People's Liberation Army Medical School, Beijing, China., Wang S; Department of Obstetrics and Gynecology, Chinese People's Liberation Army Medical School, Beijing, China., Ma Y; Department of Obstetrics and Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China., Bu X; Department of Obstetrics and Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China., Liang Y; Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University of Nationalities, Baise, Guangxi, China., Chen Y; Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University of Nationalities, Baise, Guangxi, China., Bai W; Department of Obstetrics and Gynecology, BeiJing Shijitan Hospital, Beijing, China., Chen Y; Department of Obstetrics and Gynecology, BeiJing Shijitan Hospital, Beijing, China., Deng C; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China., Zhang W; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China., Zhou M; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China., Lv L; Department of Obstetrics and Gynecology, Huanghua Development Zone Boai Hospital, Cangzhou, Hebei, China., Zhang L; Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Zhuji, Zhuji, Zhejiang, China., Lu S; Department of Clinical Research, Yikon Genomics Co., Ltd, Suzhou, Jiangsu, China., Shang W; Department of Obstetrics and Gynecology, The Seventh Medical Center of People's Liberation Army General Hospital, Beijing, China.; Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China.; Department of Obstetrics and Gynecology, Chinese People's Liberation Army Medical School, Beijing, China.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Dec 02; Vol. 15, pp. 1518288. Date of Electronic Publication: 2024 Dec 02 (Print Publication: 2024).

Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population.

Autor: Vanneste M; Department of Human Genetics, KU Leuven, Leuven, Belgium., Hoskens H; Department of Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Goovaerts S; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium., Matthews H; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium., Devine J; Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium.; Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium., Aponte JD; Department of Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Cole J; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, USA., Shriver M; Department of Anthropology, Pennsylvania State University, State College, PA, USA., Marazita ML; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Weinberg SM; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Walsh S; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA., Richmond S; Applied Clinical Research and Public Health, School of Dentistry, Cardiff University, Cardiff, UK., Klein OD; Department of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA., Spritz RA; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA., Peeters H; Department of Human Genetics, KU Leuven, Leuven, Belgium. hilde.peeters@kuleuven.be., Hallgrímsson B; Department of Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. bhallgri@ucalgary.ca.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. bhallgri@ucalgary.ca.; McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. bhallgri@ucalgary.ca., Claes P; Department of Human Genetics, KU Leuven, Leuven, Belgium. peter.claes@kuleuven.be.; Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium. peter.claes@kuleuven.be.; Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium. peter.claes@kuleuven.be.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 02; Vol. 15 (1), pp. 10458. Date of Electronic Publication: 2024 Dec 02.

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Autor: Jurgens SJ; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Rämö JT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kramarenko DR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands., Wijdeveld LFJM; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Physiology, Amsterdam UMC location, Vrije Universiteit, Amsterdam, the Netherlands., Haas J; Department of Medicine III, Institute for Cardiomyopathies Heidelberg (ICH), University Hospital Heidelberg, Heidelberg, Germany.; Site Heidelberg/Mannheim, DZHK, Heidelberg, Germany., Chaffin MD; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garnier S; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Gaziano L; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Weng LC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lipov A; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Zheng SL; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Henry A; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Palo Alto Veterans Institute for Research (PAVIR), Palo Alto Health Care System, Palo Alto, CA, USA.; Harvard Medical School, Boston, MA, USA., Challa S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rühle F; Bioinformatics Core Facility, Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany., Verdugo CD; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Krijger Juárez C; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Kany S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Cardiology, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., van Orsouw CA; Department of Clinical Genetics, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Biddinger K; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Poel E; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Elliott AL; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Harvard Medical School, Boston, MA, USA.; Department of Psychiatry and Center for Genomic Medicine, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wang X; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Francis C; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Ruan R; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Koyama S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Beekman L; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Zimmerman DS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Deleuze JF; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France.; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, Paris, France., Villard E; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Trégouët DA; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France.; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, INSERM, Bordeaux, France., Isnard R; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.; APHP, Cardiology and Genetics Departments, Pitié-Salpêtrière Hospital, Paris, France., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC location, Vrije Universiteit, Amsterdam, the Netherlands., Tadros R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Wilde AAM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; The Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Sinisalo J; Department of Cardiology, Helsinki University Hospital, Helsinki, Finland.; Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland., Niiranen T; Department of Internal Medicine, University of Turku, Helsinki, Finland.; Division of Medicine, Turku University Hospital, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Walsh R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Schmidt AF; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.; University College London British Heart Foundation Research Accelerator, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Boston University, Boston, MA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tsao PS; Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Matthews PM; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK., Ware JS; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lumbers RT; Institute of Health Informatics, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK., van der Crabben S; Department of Clinical Genetics, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Laukkanen J; Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Central Finland Biobank, Central Finland Health Care District, Jyväskylä, Finland., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Amin AS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Charron P; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.; APHP, Cardiology and Genetics Departments, Pitié-Salpêtrière Hospital, Paris, France., Meder B; Department of Medicine III, Institute for Cardiomyopathies Heidelberg (ICH), University Hospital Heidelberg, Heidelberg, Germany.; Site Heidelberg/Mannheim, DZHK, Heidelberg, Germany., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu., Daly M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland. mark.daly@helsinki.fi.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mark.daly@helsinki.fi.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. mark.daly@helsinki.fi., Aragam KG; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands. c.r.bezzina@amsterdamumc.nl.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands. c.r.bezzina@amsterdamumc.nl.

Publikováno v: Nature genetics [Nat Genet] 2024 Dec; Vol. 56 (12), pp. 2636-2645. Date of Electronic Publication: 2024 Nov 21.

The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.

Autor: Barrantes-Vidal N; Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain., Gizdic A; Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain., Torrecilla P; Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain., Mas-Bermejo P; Facultat de Biologia, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Secció de Zoologia i Antropologia Biològica, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la, Universitat de Barcelona (IBUB), Barcelona, Spain., Sheinbaum T; Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México City, México., Papiol S; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Lafit G; Department of Neurosciences, KU Leuven, Leuven, Belgium.; Department of Psychology and Education Sciences, KU Leuven, Leuven, Belgium., Myin-Germeys I; Department of Neurosciences, KU Leuven, Leuven, Belgium., Rosa A; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Facultat de Biologia, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Secció de Zoologia i Antropologia Biològica, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la, Universitat de Barcelona (IBUB), Barcelona, Spain., Kwapil TR; Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.

Publikováno v: Stress and health : journal of the International Society for the Investigation of Stress [Stress Health] 2024 Dec; Vol. 40 (6), pp. e3499. Date of Electronic Publication: 2024 Nov 14.