Zobrazeno 1 - 10
of 4 754
pro vyhledávání: '"multielectrode"'
Autor:
Meimei Yang, Daofeng You, Gang Liu, Yin Lu, Guangming Yang, Timothy O’Brien, David C. Henshall, Orla Hardiman, Li Cai, Min Liu, Sanbing Shen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (iPSC-MNs) as highly valuable models for
Externí odkaz:
https://doaj.org/article/bd6bce084c684c3aaf4f4d2a3517cc20
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Radiation therapy and stereotactic radiosurgery are common treatments for brain malignancies. However, the impact of radiation on underlying neuronal circuits is poorly understood. In the prefrontal cortex (PFC), neurons communicate via acti
Externí odkaz:
https://doaj.org/article/9a4e03ba85154673b454cd399ade98c6
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107436- (2024)
Alzheimer's disease is characterized by the aggregation of β-amyloid, a pathological feature believed to drive the neuronal loss and cognitive decline commonly seen in the disease. Given the growing prevalence of this progressive neurodegenerative d
Externí odkaz:
https://doaj.org/article/8a67380942314e249a15681836adb4a6
Autor:
Ning Ge, Rui Li, Min Liu, Wenxin Xia, Stephen T. O'Brien, Veronica McInerney, Joseph Galvin, Deirdre Ward, Catherine McGorrian, Timothy O'Brien, Sanbing Shen, Terence W. Prendiville
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Long‐QT syndrome is a primary cardiac ion channelopathy predisposing a patient to ventricular arrhythmia through delayed repolarization on the resting ECG. We aimed to establish a patient‐specific, human induced pluripotent stem cell (
Externí odkaz:
https://doaj.org/article/a5abb2f54b0f488792d176797764e91b
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
In the auditory cortex, synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), plays crucial roles in information processing and adaptation to the auditory environment. Previous rodent studies have shown lifelong
Externí odkaz:
https://doaj.org/article/bd8c8ef8f35745ec883c7b1f70183c64
Autor:
Mi-Sun Choi, Se-Myo Park, Soojin Kim, Hyun Jegal, Hyang-Ae Lee, Hyoung-Yun Han, Seokjoo Yoon, Sang-Kyum Kim, Jung-Hwa Oh
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116516- (2024)
The assessment of neurotoxicity for environmental chemicals is of utmost importance in ensuring public health and environmental safety. Multielectrode array (MEA) technology has emerged as a powerful tool for assessing disturbances in the electrophys
Externí odkaz:
https://doaj.org/article/1109831dd2084c1d9ddee85aeb091bf0
Autor:
Eva-Maria Weiss, Debarpan Guhathakurta, Aneta Petrušková, Verena Hundrup, Martin Zenker, Anna Fejtová
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
RASopathies are a group of genetic disorders caused by mutations in genes encoding components and regulators of the RAS/MAPK signaling pathway, resulting in overactivation of signaling. RASopathy patients exhibit distinctive facial features, cardiopa
Externí odkaz:
https://doaj.org/article/6614b79375604446a8d3f40b06280d1f
Autor:
Kartik S. Pradeepan, Fraser P. McCready, Wei Wei, Milad Khaki, Wenbo Zhang, Michael W. Salter, James Ellis, Julio Martinez-Trujillo
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100290- (2024)
Background: Mutations in MECP2 predominantly cause Rett syndrome and can be modeled in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell–derived ME
Externí odkaz:
https://doaj.org/article/bf64c74f1669454c9420b1a4508cfb26
Autor:
Patricia Nicolucci, Guilherme Gambaro, Kyssylla Monnyelle Araujo Silva, Iara Souza Lima, Oswaldo Baffa, Alberto Pasquarelli
Publikováno v:
Sensors, Vol 24, Iss 8, p 2409 (2024)
This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-
Externí odkaz:
https://doaj.org/article/44b2073690f441a999c8a46df6c1e73a
Autor:
Matthieu Raoux, Sandrine Lablanche, Manon Jaffredo, Antoine Pirog, Pierre-Yves Benhamou, Fanny Lebreton, Anne Wojtusciszyn, Domenico Bosco, Thierry Berney, Sylvie Renaud, Jochen Lang, Bogdan Catargi
Publikováno v:
Transplant International, Vol 36 (2023)
Islet transplantation improves metabolic control in patients with unstable type 1 diabetes. Clinical outcomes have been improving over the last decade, and the widely used beta-score allows the evaluation of transplantation results. However, predicti
Externí odkaz:
https://doaj.org/article/e05f75d0958c450d8a8ba1f5a17427ac