Metabolic Profiles of Clinical Isolates of Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis: A Metabolomics-Based Study

Autor: Wang L, Ying R, Liu Y, Sun Q, Sha W

Publikováno v: Infection and Drug Resistance, Vol Volume 16, Pp 2667-2680 (2023)

Li Wang,1,2 Ruoyan Ying,3 Yidian Liu,1,2 Qin Sun,1– 3 Wei Sha1– 3 1Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Tuberculosis

Externí odkaz: https://doaj.org/article/c5ec69a38a134c839f33fd360b823108

Transmission of Mycobacterium tuberculosis in schools: a molecular epidemiological study using whole-genome sequencing in Guangzhou, China

Autor: Ying Lin, Yuhua Du, Hongcheng Shen, Yangfeng Guo, Ting Wang, Keng Lai, Danni Zhang, Guangmin Zheng, Guifeng Wu, Yu Lei, Jianxiong Liu

Publikováno v: Frontiers in Public Health, Vol 11 (2023)

BackgroundChina is a country with a high burden of tuberculosis (TB). TB outbreaks are frequent in schools. Thus, understanding the transmission patterns is crucial for controlling TB.MethodIn this genomic epidemiological study, the conventional epid

Externí odkaz: https://doaj.org/article/45ea668ff9104dec984fd25c3d74f0ee

The Activities and Secretion of Cytokines Caused by Delamanid on Macrophages Infected by Multidrug-Resistant Mycobacterium tuberculosis Strains

Autor: Xia-Li Lyu, Ting-Ting Lin, Jing-Tao Gao, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Jing Dong, Qi Sun, Wei Shu, Li-Ping Pan, Zong-De Zhang, Qi Li

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundDelamanid (Dlm) is an effective drug against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including Multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). There are few reports on the activity and secretion of

Externí odkaz: https://doaj.org/article/a27eb5c8d402471c82f16a3ed0f6d24a

Differential protein expression in Mycobacterium tuberculosis susceptible and multidrug resistant isolates

Autor: AR Hadizadeh Tasbiti, Sh Yari, M Ghanei, SD Siadat, S Niknami, A Bahrmand

Publikováno v: Vaccine Research, Vol 3, Iss 1, Pp 26-30 (2016)

Introduction: Infections by multidrug resistant Mycobacterium tuberculosis (MDR-TB) is a major public health challenge. Secretion of proteins by M. tuberculosis plays an important role in the pathogenesis of the bacterium. We compared the protein pro

Externí odkaz: https://doaj.org/article/de8b644c5eb74f32879e32b0c30ab056

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

Autor: Nizar A. Al-Shar’i, Pobitra Borah, Katharigatta N. Venugopala, Melendhran Pillay, Pran Kishore Deb

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 869-884 (2021)

The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series of 3,5-disub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9f2bbfcbe6ebe7d649f02eff3496e2
https://doi.org/10.1080/14756366.2021.1900162