A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Autor: Natalie A. Prow, Liang Liu, Eri Nakayama, Tamara H. Cooper, Kexin Yan, Preethi Eldi, Jessamine E. Hazlewood, Bing Tang, Thuy T. Le, Yin Xiang Setoh, Alexander A Khromykh, Jody Hobson-Peters, Kerrilyn R. Diener, Paul M. Howley, John D. Hayball, Andreas Suhrbier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Zika and chikungunya virus are co-circulating in many regions and currently there is no approved vaccine for either virus. Here, the authors engineer one vaccinia virus based vaccine for both, Zika and chikungunya, and show protection from infection

Externí odkaz: https://doaj.org/article/fb33c22d0fd945c1b4999adae6928f2c

A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Autor: Kexin Yan, Alexander A. Khromykh, Jody Hobson-Peters, Bing Tang, Yin Xiang Setoh, Natalie A. Prow, Jessamine E. Hazlewood, Liang Liu, Thuy T. Le, John D. Hayball, Kerrilyn R. Diener, Tamara H. Cooper, Preethi Eldi, Andreas Suhrbier, Eri Nakayama, Paul Howley

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications

Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The “Sementis Copenhagen Vector” (SCV) system is a recently developed vaccinia-based, multiplication-defective, vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fb36cd56d04886f7645a4596978b9f
https://doi.org/10.1038/s41467-018-03662-6

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse.

Autor: Flaxman, Amy¹ (AUTHOR), Sebastian, Sarah¹ (AUTHOR), Appelberg, Sofia² (AUTHOR), Cha, Kuan M.¹ (AUTHOR), Ulaszewska, Marta¹ (AUTHOR), Purushotham, Jyothi¹ (AUTHOR), Gilbride, Ciaran¹ (AUTHOR), Sharpe, Hannah¹ (AUTHOR), Spencer, Alexandra J.¹ (AUTHOR), Bibi, Sagida³ (AUTHOR), Wright, Daniel³ (AUTHOR), Schmidt, Isabel³ (AUTHOR), Dowall, Stuart⁴ (AUTHOR), Easterbrook, Linda⁴ (AUTHOR), Findlay-Wilson, Stephen⁴ (AUTHOR), Gilbert, Sarah¹ (AUTHOR), Mirazimi, Ali² (AUTHOR), Lambe, Teresa^1,3,5 (AUTHOR) teresa.lambe@paediatrics.ox.ac.uk

Publikováno v: PLoS Pathogens. 6/26/2024, Vol. 20 Issue 6, p1-21. 21p.

New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens

Autor: Onega V. Ulianova, Valentina A. Feodorova, Vladimir L. Motin, Maria A. Khizhnyakova, Sergey S Ulyanov, Anna Lyapina, Sergey S. Zaitsev, L. V. Sayapina

Publikováno v: Vaccines, Vol 7, Iss 2, p 36 (2019)
Vaccines
Volume 7
Issue 2

Omptins represent a family of proteases commonly found in various Gram-negative pathogens. These proteins play an important role in host&ndash
pathogen interaction and have been recognized as key virulence factors, highlighting the possibility o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351cc1b0567dc98e1696ed9e27712080
https://doi.org/10.3390/vaccines7020036

Multi-pathogen based chimeric vaccine to fight against COVID-19 and concomitant coinfections.

Autor: Ojha, Rupal, Singh, Satyendra, Gupta, Nidhi, Kumar, Ketan, Padhi, Aditya K., Prajapati, Vijay Kumar

Publikováno v: Biotechnology Letters; Jul2023, Vol. 45 Issue 7, p779-797, 19p