Zobrazeno 1 - 10
of 788
pro vyhledávání: '"multi-omic"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The combination of multi-omic techniques, such as genomics, transcriptomics, proteomics, metabolomics and epigenomics, has revolutionised studies in medical research. These techniques are employed to support biomarker discovery, better under
Externí odkaz:
https://doaj.org/article/3c99835c6fa14c7eabcf400df2dc4238
Autor:
Matthew R. Gemmell, Thisun Jayawardana, Sabrina Koentgen, Ella Brooks, Nicholas Kennedy, Susan Berry, Charlie Lees, Georgina L. Hold
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract To accurately define the role of the gut microbiota in health and disease pathogenesis, the preservation of stool sample integrity, in terms of microbial community composition and metabolic function, is critical. This presents a challenge fo
Externí odkaz:
https://doaj.org/article/1170aabda07a4d358d4d4d32ce007908
Autor:
Joanna Ciantar, Saara Marttila, Sonja Rajić, Daria Kostiniuk, Pashupati P Mishra, Leo-Pekka Lyytikäinen, Nina Mononen, Marcus E Kleber, Winfried März, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Emma Raitoharju
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Eastern and Western Finns show a striking difference in coronary heart disease-related mortality; genetics is a known contributor for this discrepancy. Here, we discuss the potential role of DNA methylation in mediating the discrepancy in cardiometab
Externí odkaz:
https://doaj.org/article/2663fb4c7f7945c0a574ba69c589f2e4
Autor:
Hima Nikafshan Rad, Zheng Su, Anne Trinh, M.A. Hakim Newton, Jannah Shamsani, NYGC ALS Consortium, Abdul Karim, Abdul Sattar
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e38583- (2024)
Amyotrophic Lateral Sclerosis (ALS) is a complex and rare neurodegenerative disorder characterized by significant genetic, molecular, and clinical heterogeneity. Despite numerous endeavors to discover the genetic factors underlying ALS, a significant
Externí odkaz:
https://doaj.org/article/7e2f975503534e4c99f983ea15ba8060
Publikováno v:
mSystems, Vol 9, Iss 10 (2024)
ABSTRACT A key challenge in the analysis of microbiome data is the integration of multi-omic datasets and the discovery of interactions between microbial taxa, their expressed genes, and the metabolites they consume and/or produce. In an effort to im
Externí odkaz:
https://doaj.org/article/4033d4b20a9e4570a0ff60da1453a30c
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/ae3b21322a8144ebab92cb682208a35b
Autor:
Arianna Lodovici, Sara Buoso, Begoña Miras-Moreno, Luigi Lucini, Nicola Tomasi, Pascual García-Pérez, Roberto Pinton, Laura Zanin
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionNitrogen (N) and iron (Fe) are involved in several biochemical processes in living organisms, and their limited bioavailability is a strong constraint for plant growth and yield. This work investigated the interplay between Fe and N nutri
Externí odkaz:
https://doaj.org/article/0e579d83b1de4fba81420619ca13441e
Early detection of pancreatic cancer by liquid biopsy 'PANLIPSY': a french nation-wide study project
Autor:
Thomas Bardol, Antoine M. Dujon, Valerie Taly, Catherine Dunyach-Remy, Jean-Philippe Lavigne, Bruno Costa-Silva, Keerthi Kurma, Zahra Eslami-S, Laure Cayrefourcq, Cindy Canivet, Fabrice Muscari, Barbara Bournet, Catherine Alix-Panabières
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Pancreatic cancer, predominantly characterized by ductal adenocarcinoma (PDAC) accounts for 90% of cases and is the fourth leading cause of cancer-related deaths globally. Its incidence is notably increasing. This poor prognosis i
Externí odkaz:
https://doaj.org/article/44c5029baad6433f9786b21635522367
Autor:
Garth L. Kong, Thai T. Nguyen, Wesley K. Rosales, Anjali D. Panikar, John H. W. Cheney, Theresa A. Lusardi, William M. Yashar, Brittany M. Curtiss, Sarah A. Carratt, Theodore P. Braun, Julia E. Maxson
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background The rapid advancement of new genomic sequencing technology has enabled the development of multi-omic single-cell sequencing assays. These assays profile multiple modalities in the same cell and can often yield new insights not rev
Externí odkaz:
https://doaj.org/article/5f9df1b734eb426b9479c83d4a912b37
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Relapse remains a determinant of treatment failure and contributes significantly to mortality in acute myeloid leukemia (AML) patients. Despite efforts to understand AML progression and relapse mechanisms, findings on acquired gene mutations in relap
Externí odkaz:
https://doaj.org/article/10a40f2bfea443fd9af733d3c638f59f