Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score

Autor: Minh-Phuong, Huynh-Le, Roshan, Karunamuni, Chun Chieh, Fan, Lui, Asona, Wesley K, Thompson, Maria Elena, Martinez, Rosalind A, Eeles, Zsofia, Kote-Jarai, Kenneth R, Muir, Artitaya, Lophatananon, Johanna, Schleutker, Nora, Pashayan, Jyotsna, Batra, Henrik, Grönberg, David E, Neal, Børge G, Nordestgaard, Catherine M, Tangen, Robert J, MacInnis, Alicja, Wolk, Demetrius, Albanes, Christopher A, Haiman, Ruth C, Travis, William J, Blot, Janet L, Stanford, Lorelei A, Mucci, Catharine M L, West, Sune F, Nielsen, Adam S, Kibel, Olivier, Cussenot, Sonja I, Berndt, Stella, Koutros, Karina Dalsgaard, Sørensen, Cezary, Cybulski, Eli Marie, Grindedal, Florence, Menegaux, Jong Y, Park, Sue A, Ingles, Christiane, Maier, Robert J, Hamilton, Barry S, Rosenstein, Yong-Jie, Lu, Stephen, Watya, Ana, Vega, Manolis, Kogevinas, Fredrik, Wiklund, Kathryn L, Penney, Chad D, Huff, Manuel R, Teixeira, Luc, Multigner, Robin J, Leach, Hermann, Brenner, Esther M, John, Radka, Kaneva, Christopher J, Logothetis, Susan L, Neuhausen, Kim, De Ruyck, Piet, Ost, Azad, Razack, Lisa F, Newcomb, Jay H, Fowke, Marija, Gamulin, Aswin, Abraham, Frank, Claessens, Jose Esteban, Castelao, Paul A, Townsend, Dana C, Crawford, Gyorgy, Petrovics, Ron H N, van Schaik, Marie-Élise, Parent, Jennifer J, Hu, Wei, Zheng, Ian G, Mills, Ole A, Andreassen, Anders M, Dale, Tyler M, Seibert

Publikováno v: Huynh-Le, M-P, Karunamuni, R, Fan, C C, Asona, L, Thompson, W K, Martinez, M E, Eeles, R A, Kote-Jarai, Z, Muir, K R, Lophatananon, A, Schleutker, J, Pashayan, N, Batra, J, Grönberg, H, Neal, D E, Nordestgaard, B G, Tangen, C M, MacInnis, R J, Wolk, A, Albanes, D, Haiman, C A, Travis, R C, Blot, W J, Stanford, J L, Mucci, L A, West, C M L, Nielsen, S F, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Menegaux, F, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Rosenstein, B S, Lu, Y-J, Watya, S, Vega, A, Kogevinas, M, Wiklund, F, Penney, K L, Huff, C D, Teixeira, M R, Multigner, L, Leach, R J & UKGPCS collaborators 2022, ' Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score ', Prostate Cancer and Prostatic Diseases, vol. 25, no. 4, pp. 755-761 . https://doi.org/10.1038/s41391-022-00497-7
Prostate Cancer and Prostatic Diseases, 25(4), 755-761. Nature Publishing Group
UKGPCS Collaborators 2022, ' Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score ', Prostate Cancer and Prostatic Diseases . https://doi.org/10.1038/s41391-022-00497-7
Minh-Phuong Huynh-Le, Karunamuni, R, Fan, C C, Asona, L, Thompson, W K, Martinez, M E, Eeles, R A, Kote-Jarai, Z, Muir, K R, Lophatananon, A, Schleutker, J, Pashayan, N, Batra, J, Groenberg, H, Neal, D E, Nordestgaard, B G, Tangen, C M, MacInnis, R J, Wolk, A, Albanes, D, Haiman, C A, Travis, R C, Blot, W J, Stanford, J L, Mucci, L A, West, C M L, Nielsen, S F, Kibel, A S, Cussenot, O, Berndt, S, Koutros, S, Sorensen, K D, Cybulski, C, Grindedal, E M, Menegaux, F, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Rosenstein, B S, Lu, Y-J, Watya, S, Vega, A, Kogevinas, M, Wiklund, F, Penney, K L, Huff, C D, Teixeira, M R, Multigner, L, Leach, R J, UKGPCS Collaborators, APCB Australian Prostate Canc BioR, NC-LA PCaP Investigators, IMPACT Study Steering Comm Collabo, Canary PASS Investigators, Profile Study Steering Comm & PRACTICAL consortium 2022, ' Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score ', Prostate Cancer and Prostatic Diseases, vol. 25, pp. 755–761 . https://doi.org/10.1038/s41391-022-00497-7

Background Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whet

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