Mucin-degrading gut commensals isolated from healthy faecal donor suppress intestinal epithelial inflammation and regulate tight junction barrier function

Autor: Mingfang Pan, Nilakshi Barua, Margaret Ip

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The intestinal epithelium surface is covered by a layer of mucus that harbors a complex and dynamic population of bacteria termed gut microbiota. In particular, some gut bacteria have the ability to degrade the mucin glycan for nutritional sources. H

Externí odkaz: https://doaj.org/article/293434e46f69491da69387273e1697f5

Characterization of a phospholipid‐regulated β‐galactosidase from Akkermansia muciniphila involved in mucin degradation

Autor: Konrad Kosciow, Uwe Deppenmeier

Publikováno v: MicrobiologyOpen, Vol 8, Iss 8, Pp n/a-n/a (2019)

Abstract The gut microbe Akkermansia muciniphila is important for the human health as the occurrence of the organism is inversely correlated with different metabolic disorders. The metabolism of the organism includes the degradation of intestinal muc

Externí odkaz: https://doaj.org/article/6c9bf9dc0ea2433c95f4d98c7ea5c604

Intestinal mucus barrier: a missing piece of the puzzle in food allergy

Autor: Markus Ollert, Mahesh Desai, Marie Boudaud, Amy Parrish, Annette Kuehn

Publikováno v: Parrish, A, Boudaud, M, Kuehn, A, Ollert, M & Desai, M S 2022, ' Intestinal mucus barrier : a missing piece of the puzzle in food allergy ', Trends in Molecular Medicine, vol. 28, no. 1, pp. 36-50 . https://doi.org/10.1016/j.molmed.2021.10.004

The prevalence of food allergies has reached epidemic levels but the cause remains largely unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic sensitization to food. In this context, we focus on an important b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8c3cf135dc63d0a2cdcc0e46c640bc
https://pubmed.ncbi.nlm.nih.gov/34810087

Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development

Autor: Mi-Na Kweon, Seung Il Kim, Mi-Na Kim, Yeji Kim, Su-Hyun Lee, Yong-Soo Lee, Yun-Chan Shin, Tae-Young Kim, O. Eunju, Kwang Soon Kim

Publikováno v: Gut Microbes, Vol 13, Iss 1 (2021)
Gut Microbes
article-version (VoR) Version of Record

Mucin-degrading bacteria are densely populated in the intestinal epithelium; however, their interaction with intestinal stem cells (ISCs) and their progeny have not been elucidated. To determine whether mucin-degrading bacteria play a role in gut hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27d3314008217faf9bdfbb9928ed728
https://doaj.org/article/5ae4a36dfaa74ef5af2ebe2d86b53e24

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