Zobrazeno 1 - 10
of 933
pro vyhledávání: '"mtDNA mutations"'
Autor:
Mohammed Dashti, Naser M. Ali, Hussain Alsaleh, Sumi Elsa John, Rasheeba Nizam, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThe Kuwaiti and Qatari populations have a high prevalence of obesity, a major risk factor for various metabolic disorders. Previous studies have independently explored mitochondrial DNA (mtDNA) variations and their association with obesity
Externí odkaz:
https://doaj.org/article/92b674ae9c274b6d89347513b9c5fc19
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Autor:
Chao Chen, Min-Xin Guan
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited with 37 genes, encoding 13 polypeptides for oxidative phosphory
Externí odkaz:
https://doaj.org/article/a0a3e179970d4d8d9c1085976cd29370
Autor:
Taisiya V. Tolstik, Tatiana V. Kirichenko, Anastasia I. Bogatyreva, Yuliya V. Markina, Vladislav A. Kalmykov, Alexander M. Markin
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 16, Iss 1, p 6 (2024)
Background: Metabolic disorders, including obesity, are often accompanied by an increased risk of cardiovascular complications. Monocytes are the common link between obesity and cardiovascular diseases (CVDs). The bias of innate cellular immunity tow
Externí odkaz:
https://doaj.org/article/89817a556a994530919ec0e1caaaad35
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 139-149 (2023)
Xiao-Chao Dong,1 Chang Liu,1 Guang-Chao Zhuo,2 Yu Ding2 1Department of Gynecology and Obstetrics, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Central Laboratory, Hangzhou First
Externí odkaz:
https://doaj.org/article/0781ae87c0924a50a2d51e7d18a9d341
Autor:
Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Júnior, Christiaan Leeuwenburgh, Cecilia Bucci, Emanuele Marzetti
Publikováno v:
Experimental Gerontology, Vol 178, Iss , Pp 112203- (2023)
Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to endogenous and/or environmental stressors. The coordination of mtDNA replication and transcripti
Externí odkaz:
https://doaj.org/article/d384bf8041714f879652e58f851242f8
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 8, Pp 1467-1482 (2021)
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manife
Externí odkaz:
https://doaj.org/article/9d465facc3444f4ea52e72f70ce70a72
Autor:
I. R. Gazizova, I. O. Mazunin, T. N. Malishevskaya, O. A. Kiseleva, A. M. Gadzhiev, Al.-M. Rindzhibal
Publikováno v:
Oftalʹmologiâ, Vol 16, Iss 4, Pp 479-486 (2019)
Currently, the mitochondrial component is becoming increasingly significant in the development and progression of glaucoma optic neuropathy. Since mitochondria have their own genetic apparatus, the study of qualitative and quantitative changes in mit
Externí odkaz:
https://doaj.org/article/33d554669aef44a4bedb0e4e6290906e
Autor:
Sanjana Saravanan, Caitlin J. Lewis, Bhavna Dixit, Matthew S. O’Connor, Alexandra Stolzing, Amutha Boominathan
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 490 (2022)
Mitochondria are intracellular organelles that utilize nutrients to generate energy in the form of ATP by oxidative phosphorylation. Mitochondrial DNA (mtDNA) in humans is a 16,569 base pair double-stranded circular DNA that encodes for 13 vital prot
Externí odkaz:
https://doaj.org/article/409bea393f7144ba82b88627923cd094
Autor:
Francesco Musiani, Laura Rigobello, Luisa Iommarini, Valerio Carelli, Mauro Degli Esposti, Anna Maria Ghelli
Publikováno v:
Molecules, Vol 27, Iss 4, p 1341 (2022)
The finding that the most common mitochondrial DNA mutation m.11778G>A/MT-ND4 (p.R340H) associated with Leber’s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evid
Externí odkaz:
https://doaj.org/article/0c192a7c09314478b05d3f3e31bdec6b
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2627 (2022)
In the past decade, anti-tumour immune responses have been successfully exploited to improve the outcome of patients with different cancers. Significant progress has been made in taking advantage of different types of T cell functions for therapeutic
Externí odkaz:
https://doaj.org/article/eb2512386c974cefaef43c322dc0c1ea