Zobrazeno 1 - 10
of 1 277
pro vyhledávání: '"mrna degradation"'
Autor:
Pedro Tomaz da Silva, Yujie Zhang, Evangelos Theodorakis, Laura D Martens, Vicente A Yépez, Vicent Pelechano, Julien Gagneur
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 506-520 (2024)
Abstract Codon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. Here we show that codon optimality associates with up to 2-
Externí odkaz:
https://doaj.org/article/886dcbd4f491450cb29550ad858c2b8d
Autor:
Vincenzo Cianci, Cristina Mondello, Daniela Sapienza, Maria Cristina Guerrera, Alessio Cianci, Annalisa Cracò, Fausto Omero, Vittorio Gioffrè, Patrizia Gualniera, Alessio Asmundo, Antonino Germanà
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8185 (2024)
Although the postmortem interval estimation still represents one of the main goals of forensic medicine, there are still several limitations that weigh on the methods most used for its determination: for this reason, even today, precisely estimating
Externí odkaz:
https://doaj.org/article/2d32621a4c3c41bda5553fbf4b9ef43f
Autor:
Dong-Yue Wang, Juan Zhu, Yi-Zhong Zhang, Qian-Yi Cui, Shan-Shan Wang, Yang-Wei Ning, Xing-Jia Shen
Publikováno v:
Insects, Vol 15, Iss 5, p 313 (2024)
Genetic mutations leading to premature termination codons are known to have detrimental effects. Using the Lepidoptera model insect, the silkworm (Bombyx mori), we explored the genetic compensatory response triggered by mutations with premature termi
Externí odkaz:
https://doaj.org/article/740c4bb63be34e1e92411f7ddc66ebcc
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Studies have shown that sperm-borne microRNAs (miRNAs) are involved in mammalian preimplantation embryonic development. In humans, spermatozoan miR-34c levels are correlated with in vitro fertilization outcomes, such as embryo qua
Externí odkaz:
https://doaj.org/article/53c063bf2fc44b7ab21858d6bfc39e1c
Autor:
Weizhou Wang, Mengmeng Zhao, Haiyang Zuo, Jingyao Zhang, Bin Liu, Fu Chen, Pengyun Ji, Guoshi Liu, Shuai Gao, Wei Shang, Lu Zhang
Publikováno v:
Reproduction and Fertility, Vol 4, Iss 2, Pp 1-12 (2023)
The transition of maternal to zygotic gene expression regulation is critical for human preimplantation embryo development. In recent years, single-cell RNA sequencing (scRNA-seq) had been applied to detect the factors that regulate human oocyte matur
Externí odkaz:
https://doaj.org/article/0346f2359c9f477d80a8902041d04933
Autor:
Emma McHugh, Michaela S. Bulloch, Steven Batinovic, Cameron J. Patrick, Drishti K. Sarna, Stuart A. Ralph
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional r
Externí odkaz:
https://doaj.org/article/f970a0b75e754aad8d5c1abc6f26484e
Autor:
Shuilian Wu, Haotian Xu, Ruirui Zhang, Xin Wang, Jialei Yang, Xiaofei Li, Sixian Chen, Wanting He, Aruo Nan
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 742-754 (2022)
The circular RNA (circRNA) circLAMA3 is significantly downregulated in bladder cancer tissues and cell lines. However, its function in bladder cancer has not yet been explored, and further research is needed. In this study, functional experiments dem
Externí odkaz:
https://doaj.org/article/03fadcc655344ef09d470f03dfe77f64
Akademický článek
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Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins. A
Externí odkaz:
https://doaj.org/article/d9b65df3d2c44430a7ca1c596f183936
Akademický článek
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