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Akademický článek

Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting

Autor: Maryam Mahmoudian Esfahani, Maryam Mostashfi, Shiva Vaheb Hosseinabadi, Motahare-Sadat Hashemi, Maryam Peymani, Dina Zohrabi, Seyed Abdolhamid Angaji, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi

Publikováno v: Neuroscience Research, Vol 203, Iss , Pp 18-27 (2024)

In this study, we explored the regulatory role of microRNA miR-101-3p on the zinc finger protein 746 (ZNF746), also known as PARIS, which is implicated in both sporadic and familial forms of Parkinson's disease. In a Parkinson's disease cell model, u

Externí odkaz: https://doaj.org/article/d3a06fff6a6e46d1b15bd0f54b14a68d

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Akademický článek

Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease

Autor: Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Yi-Ru Chen, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen, Guey-Jen Lee-Chen

Publikováno v: Frontiers in Aging Neuroscience, Vol 16 (2024)

BackgroundIn Parkinson's disease (PD) brains, microglia are activated to release inflammatory factors to induce the production of reactive oxygen species (ROS) in neuron, and vice versa. Moreover, neuroinflammation and its synergistic interaction wit

Externí odkaz: https://doaj.org/article/d2ad577bd4044808aafb1de80cb17078

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Akademický článek

Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway

Autor: Carolina Petri Bernardes, Ernesto Lopes Pinheiro Junior, Isabela Gobbo Ferreira, Isadora Sousa de Oliveira, Neife Aparecida Guinaim dos Santos, Suely Vilela Sampaio, Eliane Candiani Arantes, Antonio Cardozo dos Santos

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 30 (2024)

Abstract Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. There is no effective treatment for neurodegenerative diseases. Snake venoms are a cocktail of proteins and peptides with great therapeutic potent

Externí odkaz: https://doaj.org/article/d087aeac3dd04f36990c5e7f1723446c

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Akademický článek

Alleviative and Anti-Inflammatory effects of tuna blood hydrolysates on MPP+ and TNF-α - induced Parkinson-Like disease model through the regulation of Keap1-Nrf2 antioxidant pathway and apoptosis

Autor: Panlekha Rungruang, Daraphan Rodthayoy, Mantira Hawangjoo, Wanwimol Klaypradit, Pennapa Chonpathompikunlert, Veerawat Sansri, Chayapat Uthayopas, Morakot Sroyraya

Publikováno v: Journal of Functional Foods, Vol 116, Iss , Pp 106134- (2024)

The pathophysiology of Parkinson's disease (PD) is linked to oxidative stress and inflammatory-induced cell death of dopaminergic neurons in substantia nigra pars compacta (SNpc). The current study aims to investigate the effects of tuna blood hydrol

Externí odkaz: https://doaj.org/article/2ca77d4253f64f51834098973dd721c4

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Akademický článek

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Akademický článek

Altered expression of miR-29a-3p and miR-34a-5p by specific inhibition of GSK3β in the MPP+ treated SH-SY5Y Parkinson's model

Autor: Morteza Ahmadzadeh-Darinsoo, Mojtaba Ahmadzadeh-Darinsoo, Shahsanam Abbasi, Ehsan Arefian, Claude Bernard, Azita Parvaneh Tafreshi

Publikováno v: Non-coding RNA Research, Vol 7, Iss 1, Pp 1-6 (2022)

In the current study, the effects of 7-BIO as a specific GSK3β inhibitor was examined on cell survival and expression of miR-29a-3p and miR-34a-5p in neurotoxin MPP+ treated SH-SY5Y cells. Our findings revealed that while co-treatment of the cells w

Externí odkaz: https://doaj.org/article/b1f14dd059b74b109f34bb8da9e92710

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Akademický článek

Effects of propofol on neuroblastoma cells via the HOTAIRM1/miR-519a-3p axis

Autor: Wang Guan, Yu Yao, Wang Yang

Publikováno v: Translational Neuroscience, Vol 13, Iss 1, Pp 57-69 (2022)

Propofol, an intravenous sedative-hypnotic agent, is demonstrated to have antioxidant properties. The purpose of this study is to investigate the functional roles of propofol in neuroblastoma cells.

Externí odkaz: https://doaj.org/article/3ad2a64b1e584235a9adccb1be3a7773

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Akademický článek

Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model

Autor: Elvis Cuevas, Aida Guzman, Susan M. Burks, Alejandro Ramirez-Lee, Syed F. Ali, Syed Z. Imam

Publikováno v: Toxicology Reports, Vol 9, Iss , Pp 806-813 (2022)

The pathophysiology underlying the loss of dopaminergic neurons in Parkinson’s disease (PD) is unclear. A gap of knowledge in the molecular and cellular events leading to degeneration of the nigrostriatal DA system is a major barrier to the develop

Externí odkaz: https://doaj.org/article/659cd74f08e64897b54d3a68fe7918d1

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