Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction

Autor: David Fleck, Ileana L. Hanganu-Opatz, Lingzhen Song, Peggy Putthoff, Xiaxia Xu, Marc Spehr

Publikováno v: PubMed Central
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The Journal of Neuroscience
The journal of neuroscience 42(4), 601-618 (2022). doi:10.1523/JNEUROSCI.1203-21.2021

Precise information flow from the hippocampus (HP) to prefrontal cortex (PFC) emerges during early development and accounts for cognitive processing throughout life. On flip side, this flow is selectively impaired in mental illness. In mouse models o

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